WikiJournal of Medicine/Epidemiology of the Hepatitis D virus

From Wikiversity
Jump to navigation Jump to search

WikiJournal of Medicine logo.svg

WikiJournal of Medicine
Wikipedia-integrated • Public peer review • Libre open access

WikiJournal of Medicine is an open-access, free-to-publish, Wikipedia-integrated academic journal for Medical and Biomedical topics. <seo title=" WJM, WikiJMed, Wiki.J.Med., WikiJMed, Wikiversity Journal of Medicine, WikiJournal Medicine, Wikipedia Medicine, Wikipedia medical journal, WikiMed, Wikimedicine, Wikimedical, Medicine, Biomedicine, Free to publish, Open access, Open-access, Non-profit, online journal, Public peer review "/>

<meta name='citation_doi' value='10.15347/wjm/2020.001.2'>

Article information

Author: Mario Rizzetto[a][i]ORCID iD.svg 

"Epidemiology of the Hepatitis D virus", WikiJournal of Medicine, 7 (1): 1, 2020, doi:10.15347/WJM/2020.001.2, ISSN 2002-4436, Wikidata Q89093122




Abstract

Hepatitis D is a globally occurring liver disease. It afflicts those who have been infected by both the Hepatitis B virus (HBV) and also the Hepatitis D virus (HDV), since HDV needs the hepatitis B surface antigen (HBsAg) to replicate. It is therefore most prevalent in countries where HBV infection is also common, currently the Amazon basin and low income regions of Asia and Africa. Improved measures to control HBV in industrialised countries (such as by vaccination) have also reduced the prevalence of HDV, with the main remaining at-risk populations in those countries being injection drug users and immigrants from endemic HDV areas.

Main text

Hep D Epidemiology Figure 1.svg

Figure 1 |  Worldwide prevalence of HDV among HBV carriers in 2015. Eight genotypes have been identified worldwide by comparative phylogenetic analysis. Genotype 1 is the most frequent and has variable pathogenicity, Genotypes 2 and 4 are found in East Asia causing relatively mild disease. Genotype 3 is found in South America in association with severe hepatitis. Genotypes 5, 6, 7, 8 have been found only in Africa.

The hepatitis D virus (HDV) occurs worldwide.[1] Although the figures are disputed, a recent systematic review suggests that up to 60 million individuals could be infected.[2] The major victims are the carriers of the hepatitis B surface antigen (HBsAg), who become superinfected by the HDV, and intravenous drug users are the group at highest risk. The infection usually results in liver damage (hepatitis D); this is most often a chronic and severe hepatitis rapidly conducive to cirrhosis.[1]

Infection with the HDV is recognized by the finding of the homologous antibody (anti-HD) in serum. Testing for the viral genome (HDV RNA) is limited. In 2013, the 1st World Health Organization International Standard of HDV RNA for nucleic acid amplification techniques (NAT)-based assays was developed.[3]

The underlying HBV infection required to support the HDV is critical to determine the outcome of hepatitis D.[4] In simultaneous coinfection with the HBV, the HDV is rescued by the partner HBV with which it shares the HBsAg coat; in superinfections of HBsAg carriers, it is rescued by the foreign HBV of the carrier which provides the HBsAg coat for the assembly of the HD virion. Coinfections run an acute course; expression of the HDV is accompanied by a weak and transient antibody response and is ephemeral.

In superinfections, the chronic HBV infection and HBsAg state indefinitely sustains the replication of the HDV, resulting in a persistent anti-HD response that can be detected in any random blood sample over time; therefore, carriers of the HBsAg are the only reliable source of epidemiological information. However, HDV infections are highly pathogenic and induce the development of liver cirrhosis in approximately 70% of cases within five to ten years, with the risk of cirrhosis threefold higher in HDV-HBV co-infected than in HBV mono-infected patients.[5] As the probability of finding anti-HD throughout the clinical spectrum of HBV liver disorders increases in parallel with the severity of the liver disease. Patients with advanced HBV liver disease are the most suitable category of HBV carriers to determine the epidemiology and real health burden of HDV.

Low HDV endemicity areas are North America, North Europe and Australia, where it is virtually confined to intravenous drug users and immigrants from infected areas.[6] High endemicity areas remain in the Amazon basin and low income regions of Asia and Africa; outbreaks and fulminant hepatitis D were reported in the past in the Brazilian and Peruvian Amazon, the Central African Republic, the Himalayan foothills[1] and after the year 2000, in Samara (Russia), Greenland and Mongolia.[6]

By controlling HBV infection, the implementation of hepatitis B vaccination in the industrialized world has led to a marked reduction of HDV[6] particularly in Southern Europe and Taiwan. In Italy, HDV diminished among HBV liver disorders from 24.6% in 1983 to 8% in 1997. The residual prevalence of chronic hepatitis D in HBV liver diseases in Western Europe is, as of 2010, between 4.5% and 10%, with immigrants from endemic HDV areas accounting for the larger proportion of cases.[7]

The risk of HDV has not significantly changed in recent years in countries of the world where HBV remains uncontrolled. In Asia up to 2015, the highest prevalences of chronic HDV liver disease were reported in Pakistan, Iran, Tajikistan, and Mongolia;[8][9] (Figure 1) a 2019 study has shown that over 80% of HBsAg cirrhosis cases in Uzbekistan are associated with HDV infection.[10] From partial and scattered information the prevalence in China, India and Indonesia appears to be low.

In many countries of Africa, the role of hepatitis D is unknown for lack of testing. The highest rates of HDV infection were reported in sub-Saharan Africa,[11][12] with the finding of anti-HD in over 30% and 50% of the general HBsAg population of Gabon and Cameroon, respectively, and in over 50% of the HBsAg cirrhotics in the Central African Republic (Figure 1). Lesser but consistent antibody rates (from 20% to 43%, with a mean of 24%) were reported in HBsAg liver disease in Tunisia, Mauritania, Senegal, Nigeria, Somalia and upper Egypt. Low prevalences of 2.5% and 12.7% have been reported in HBV disease carriers in Libya and Ethiopia.

Low prevalence of 0 to 8% has also been reported from Morocco, Algeria, Burkina-Faso, Benin, Mali, Sudan, South Africa and Mozambique; however, they were derived from asymptomatic HBsAg-carriers at low risk of HDV, collected at blood banks and in pregnancy clinics.

Conclusion

Chronic hepatitis D represents the most ominous form of chronic viral liver disorders and the one for which there is at present no efficacious therapy. Limitations of sexual contacts, use of condoms, avoidance of direct contact with blood and of the sharing of sharp items between HDV-infected and non infected HBV carriers, whenever feasible, may help to diminish the risk. Control of the HBV by the implementation of HBV vaccination programs is bound to diminish and ultimately eradicate HDV infection.

Additional information

Competing interests

Author declares no competing interests

References

  1. 1.0 1.1 1.2 Smedile, A; Rizzetto, M; Gerin, J (February 1994). "Advances in hepatitis D virus biology and disease". Progress in Liver Diseases 12: 157–175. ISSN 1060-913X. OCLC 1587746. https://www.researchgate.net/publication/15452064_Advances_in_hepatitis_D_virus_biology_and_disease. 
  2. Stockdale, Alexander J; Kreuels, Benno; Henrion, Marc R Y; Giorgi, Emanuele; Kyomuhangi, Irene; Geretti, Anna Maria (2020). "Hepatitis D prevalence: problems with extrapolation to global population estimates". Gut 69 (2): 396–397. doi:10.1136/gutjnl-2018-317874. ISSN 0017-5749. http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-317874. 
  3. Chudy, Michael; Hanschmann, Kay-Martin; Bozdayi, Mithat; Kreß, Julia; Nübling, C. Micha (October 2013). "Collaborative Study to Establish a World Health Organization International Standard for Hepatitis D Virus RNA for Nucleic Acid Amplification Technique (NAT)-Based Assays" (PDF). who.int. World Health Organization. Retrieved January 2, 2020.
  4. Farci, Patrizia (2003). "Delta hepatitis: An update". Journal of Hepatology 39: 212–219. doi:10.1016/S0168-8278(03)00331-3. PMID 14708706. 
  5. Fattovich, G.; Giustina, G.; Christensen, E.; Pantalena, M.; Zagni, I.; Realdi, G.; Schalm, S. W. (2000). "Influence of hepatitis delta virus infection on morbidity and mortality in compensated cirrhosis type B". Gut 46 (3): 420–426. doi:10.1136/gut.46.3.420. PMID 10673308. PMC 1727859. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1727859/. 
  6. 6.0 6.1 6.2 Rizzetto, Mario; Ciancio, Alessia (August 2012). "Epidemiology of Hepatitis D". Seminars in Liver Disease 32 (3): 211–219. doi:10.1055/s-0032-1323626. ISSN 0272-8087. http://dx.doi.org/10.1055/s-0032-1323626. 
  7. Wedemeyer, Heiner; Manns, Michael P. (2010). "Epidemiology, pathogenesis and management of hepatitis D: Update and challenges ahead". Nature Reviews Gastroenterology & Hepatology 7 (1): 31–40. doi:10.1038/nrgastro.2009.205. PMID 20051970. 
  8. Abbas, Zaigham (2010). "Hepatitis D: Scenario in the Asia-Pacific region". World Journal of Gastroenterology 16 (5): 554. doi:10.3748/wjg.v16.i5.554. ISSN 1007-9327. http://dx.doi.org/10.3748/wjg.v16.i5.554. 
  9. Alfaiate, Dulce; Dény, Paul; Durantel, David (2015). "Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options". Antiviral Research 122: 112–129. doi:10.1016/j.antiviral.2015.08.009. ISSN 0166-3542. http://dx.doi.org/10.1016/j.antiviral.2015.08.009. 
  10. Khodjaeva, Malika; Ibadullaeva, Nargiz; Khikmatullaeva, Aziza; Joldasova, Elizaveta; Ismoilov, Umed; Colombo, Massimo; Caviglia, Gian Paolo; Rizzetto, Mario et al. (2019). "The medical impact of hepatitis D virus infection in Uzbekistan". Liver International 39 (11): 2077–2081. doi:10.1111/liv.14243. PMID 31505080. 
  11. Rizzetto, Mario (2019). "Hepatitis D Virus". In Wong, Robert J.; Gish, Robert G. (eds.). Clinical Epidemiology of Chronic Liver Diseases. pp. 135–148. doi:10.1007/978-3-319-94355-8_11. ISBN 978-3-319-94355-8.
  12. Stockdale, Alexander J.; Chaponda, Mas; Beloukas, Apostolos; Phillips, Richard Odame; Matthews, Philippa C.; Papadimitropoulos, Athanasios; King, Simon; Bonnett, Laura et al. (2017). "Prevalence of hepatitis D virus infection in sub-Saharan Africa: A systematic review and meta-analysis". The Lancet Global Health 5 (10): e992–e1003. doi:10.1016/S2214-109X(17)30298-X. PMID 28911765. PMC 5599428. //www.ncbi.nlm.nih.gov/pmc/articles/PMC5599428/.