WikiJournal of Medicine/Volume 9 Issue 1
WikiJournal of Medicine
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VOLUME 9 (2022)
ISSUE 1
Previous issue
Author: Joseph Cusimano
Rabeprazole is a proton pump inhibitor that suppresses gastric acid production in the stomach. Available under different brand name products as well as in a variety of combination products, rabeprazole has several medical uses concerning the management of problems of pathological gastric acid. Rabeprazole's adverse effects tend to be mild but can be serious, including deficiencies in essential nutrients, rare incidences of liver damage, and immune-mediated reactions. As a class effect, rabeprazole can increase the risk for osteoporosis, serious infections (including Clostridium difficile infections), and kidney damage. Rabeprazole can theoretically contribute to numerous drug interactions, mediated both through its metabolic properties and its direct effect on acid in the stomach, though its potential for clinically meaningful drug interactions is low. Like other medications in the proton pump inhibitor class, rabeprazole's mechanism of action involves the irreversible inhibition of proton pumps in the stomach, which are responsible for gastric acid production. Rabeprazole has a number of chemical metabolites, though it is primarily degraded by non-enzymatic metabolism and excreted in the urine. Genetic differences in a person's drug-metabolizing enzymes may theoretically affect individual responses to rabeprazole therapy, though the clinical significance of this interaction is unlikely in comparison to other proton pump inhibitors. The purpose of this review is to provide an up-to-date monograph on rabeprazole.
doi: 10.15347/WJM/2022.006
Author: Kholhring Lalchhandama
The history of coronaviruses is an account of the discovery of coronaviruses and the diseases they cause. It starts with a report of a new type of upper-respiratory tract disease among chickens in North Dakota, US, in 1931. The causative agent was identified as a virus in 1933. By 1936, the disease and the virus were recognised as unique from other viral diseases. The virus became known as infectious bronchitis virus (IBV), but later officially renamed as Avian coronavirus. A new brain disease of mice (murine encephalomyelitis) was discovered in 1947 at Harvard Medical School in Boston. The virus was called JHM (after Harvard pathologist John Howard Mueller). Three years later a new mouse hepatitis was reported from the National Institute for Medical Research in London. The causative virus was identified as mouse hepatitis virus (MHV), later renamed Murine coronavirus. In 1961, a virus was obtained from a school boy in Epsom, England, who was suffering from common cold. The sample, designated B814, was confirmed as novel virus in 1965. New common cold viruses (assigned 229E) collected from medical students at the University of Chicago were also reported in 1966. Structural analyses of IBV, MHV, B18 and 229E using transmission electron microscopy revealed that they all belong to the same group of viruses. Making a crucial comparison in 1967, June Almeida and David Tyrrell invented the collective name coronavirus, as all those viruses were characterised by solar corona-like projections (called spikes) on their surfaces. Other coronaviruses have been discovered from pigs, dogs, cats, rodents, cows, horses, camels, Beluga whales, birds and bats. As of 2022, 52 species are described. Bats are found to be the richest source of different species of coronaviruses. All coronaviruses originated from a common ancestor about 293 million years ago. Zoonotic species such as Severe acute respiratory syndrome-related coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a variant of SARS-CoV, emerged during the past two decades and caused the first pandemics of the 21st century.
doi: 10.15347/WJM/2022.005
Author: Siang Ching Raymond Chieng
This review article is written to give a comprehensive and yet straightforward overview regarding a tropical disease named melioidosis. Besides that, this article also aims to promote awareness and research in the disease. Melioidosis is an infectious disease that ravages the tropical regions around the world. However, the awareness of this disease is lacking in developing countries. It is not even included in the WHO list of Neglected Tropical Disease. The ability of this disease to spread through air by inhalation makes it a potential agent for bioweapons, although there is no documented evidence of its use in biological warfare. There are also various gaps of research in melioidosis. A search into PubMed and Google Scholar was done by using keywords "melioidosis", "melioidosis biological agent", "Burkholderia pseudomallei", "human melioidosis", and "melioidosis review" while writing this review. Allocation of resources into the study and prevention of melioidosis will help to improve the disease burden in developing countries.
doi: 10.15347/WJM/2022.004
Authors: Richard Abidin, Logan Smith, Hannah Kim, Eric Youngstrom
Parenting Stress relates to stressors that are a function of being in and executing the parenting role. It is a construct that relates to both psychological phenomena and to the human body’s physiological state as a parent or caretaker of a child. This article serves as a brief narrative review of the construct.
doi: 10.15347/WJM/2022.003
Author: Siang Ching Raymond Chieng
This article aims to provide a comprehensive overview of the infectious zoonotic disease Leptospirosis in tropical countries. Warm blooded animals such as mice, dogs, and cows can be infected by this disease and carry the disease to humans. Although cold blooded animals such as reptiles may have Leptospira bacteria in them, their role in causing diseases in humans are unknown. Once infected, symptoms can range from mild disease to life-threatening ones. The pathogenesis of the leptospirosis infection is not completely understood. Therefore, more researches are required to understand the disease. Searches into PubMed and Google Scholar were done by using keywords "leptospirosis", "human leptospirosis", "animal leptospirosis", "Leptospira", and "leptospirosis review" while writing this article. In conclusion, leptospirosis is a common disease in the tropics and the public should know the effective ways of avoiding or treating the disease.
doi: 10.15347/WJM/2022.002
Author: Osmin Anis
The Kivu Ebola epidemic began on 1 August 2018, when four cases of Ebola virus disease (EVD) were confirmed in the eastern region of Kivu in the Democratic Republic of the Congo (DRC). The disease affected the DRC, Uganda, and is suspected to have also affected Tanzania, though the Ministry of Health there never shared information with the WHO. The outbreak was declared ended on 25 June 2020, with a total of 3,470 cases and 2,280 deaths. [...] Other locations in the DRC affected included the Ituri Province, where the first case was confirmed on 13 August 2018. In November 2018, it became the biggest Ebola outbreak in the DRC's history, and by November, it had become the second-largest Ebola outbreak in recorded history, behind only the 2013–2016 Western Africa epidemic. On 3 May 2019, 9 months into the outbreak, the DRC death toll surpassed 1,000. In June 2019, the virus reached Uganda, having infected a 5-year-old Congolese boy who entered with his family, but this was contained. Since January 2015, the affected province and general area have been experiencing a military conflict, which hindered treatment and prevention efforts. The World Health Organization (WHO) has described the combination of military conflict and civilian distress as a potential "perfect storm" that could lead to a rapid worsening of the situation. In May 2019, the WHO reported that, since January of that year, there had been 42 attacks on health facilities and 85 health workers had been wounded or killed. In some areas, aid organizations have had to stop their work due to violence. Health workers also had to deal with misinformation spread by opposing politicians. Due to the deteriorating security situation in North Kivu and surrounding areas, the WHO raised the risk assessment at the national and regional level from "high" to "very high" in September 2018. In October, the United Nations Security Council stressed that all armed hostility in the DRC should come to a stop to address the ongoing outbreak better. A confirmed case in Goma triggered the decision by the WHO to convene an emergency committee for the fourth time, and on 17 July 2019, the WHO announced a Public Health Emergency of International Concern (PHEIC), the highest level of alarm the WHO can sound. On 15 September 2019, some slowdown of cases was noted in the DRC. However, contact tracing continued to be less than 100%; at the time, it was at 89%. In mid-October the transmission of the virus had significantly reduced; by then it was confined to the Mandima region near where the outbreak began, and was only affecting 27 health zones in the DRC (down from a peak of 207). New cases decreased to zero by 17 February 2020, but after 52 days without a case, surveillance and response teams confirmed three new cases in mid-April. As a new and separate outbreak, was reported on 1 June 2020 in Équateur Province in north-western DRC, described as the eleventh Ebola outbreak since records began; after almost two years the tenth outbreak was declared ended on 25 June 2020, with a total of 3,470 cases and 2,280 deaths. doi: 10.15347/WJM/2022.001
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