Talk:Motivation and emotion/Book/2016/Antidepressants and emotion
Hello, i thought i might give a bit of information since this is an area i'm very interested in and have done alot of research about. Drugs that inhibit reuptake of serotonin have a tendency to 'numb' and 'blunt' emotions, both positive and negative
http://bjp.rcpsych.org/content/195/3/211 Emotional side-effects of selective serotonin reuptake inhibitors: qualitative study
This study found that SSRI's inhibit the amygdala response It also found that Norepinephrine reuptake inhibitors increase activation in the thalamus and the cingulate cortex http://www.sciencedirect.com/science/article/pii/S0149763413001814 Acute neural effects of selective serotonin reuptake inhibitors versus noradrenaline reuptake inhibitors on emotion processing: Implications for differential treatment efficacy
There are also different types of antidepressants, such as MAOI's, and medicines that act on certain receptors (Buspar, Mirtazapine, Vilazodone, Trazodone) Here is an article on mirtazapine http://www.ncbi.nlm.nih.gov/pubmed/19031070 Early effects of mirtazapine on emotional processing.
Generally the antidepressants have varying and sporadic effects on emotion. drugs that affect dopamine and norepinephrine have a tendency to increase emotion whereas serotonergic drugs tend to decrease it. But it varies wildly given the individual differences in people taking it.
A very very interesting antidepressant that i think would be definately worth mentioning in your book chapter is 'Tianeptine' http://tianeptine.com/
It enhances the reuptake of serotonin, as opposed to inhibiting it as SSRI's do, and has been found to be more effective Here are some articles on it http://zh9bf5sp6t.scholar.serialssolutions.com/?sid=google&auinit=V&aulast=Novotny&atitle=Tianeptine+and+fluoxetine+in+major+depression:+a+6%E2%80%90week+randomised+double%E2%80%90blind+study&id=doi:10.1002/hup.411&title=Human+psychopharmacology&volume=17&issue=6&date=2002&spage=299&issn=0885-6222 Tianeptine and fluoxetine in major depression: a 6-week randomised double-blind study
http://zh9bf5sp6t.scholar.serialssolutions.com/?sid=google&auinit=AJ&aulast=Wagstaff&atitle=Tianeptine&id=doi:10.2165/00023210-200115030-00006&title=CNS+drugs&volume=15&issue=3&date=2001&spage=231&issn=1172-7047 Tianeptine A Review of its Use in Depressive Disorders
Here is another references that might be interesting http://ac.els-cdn.com/S0278584610002885/1-s2.0-S0278584610002885-main.pdf?_tid=ebae3156-7689-11e6-a54e-00000aacb35d&acdnat=1473424721_12e429931b7e297316286efd0f0d05bf Arlo --Arlo Porter (discuss • contribs) 12:51, 9 September 2016 (UTC)
Hello just found an article, hope you will be interested, it talks about mental blunting after taking antidepressants, also discusses generally about what usual problems people suffer from taking antidepressants. the title is'The Oxford Questionnaire on the Emotional Side-effects of Antidepressants (OQuESA): Development, validity, reliability and sensitivity to change'http://www.sciencedirect.com.ezproxy.canberra.edu.au/science/article/pii/S0165032712000778--U3121927 (discuss • contribs) 09:58, 22 October 2016 (UTC)
User:U3166203, avoid having a single sub-section within a section; either add another sub-section or merge the content into the higher level section. -- Jtneill - Talk - c 21:48, 23 October 2016 (UTC)
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