Talk:WikiJournal Preprints/CARD-CC family
Add topic
This article is an unpublished pre-print undergoing public peer review organised by the WikiJournal of Science.
It is adapted from the Wikipedia page CARD-CC family. It contains some or all of that page's content licensed under a Creative Commons Attribution ShareAlike License and will also be used to update that article after peer review.You can follow its progress through the peer review process at this tracking page.First submitted:
QID: Q116768204
Suggested (provisional) preprint citation format:
Jens Staal. "CARD-CC family". WikiJournal Preprints. Wikidata Q116768204.
License: 
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction, provided the original author and source are credited.
Henry Hoff 
contact
Daniel Krappmann
anonymous
Iva Hafner-Bratkovič
Article information
This is the pre-publication public peer review for the article CARD-CC family
Plagiarism check
[edit source]
Pass. Report from WMF copyvios tool: only trivial overleap with other sources such as "and motor proteins, and transcription factors". T.Shafee(Evo﹠Evo)talk 22:46, 8 February 2023 (UTC)
Editorial comments
[edit source]
Comments by Andrew Leung 
,
These editorial comments were submitted on , and refer to this previous version of the article
Similar to WikiJournal Preprints/MALT1, I would like to see the following points to be improved before sending it to peer reviewers:
- The evolution and species distribution covered the history aspect from an evolutionary perspective. It should provide a brief history on how it was discovered (and by whom). See WikiJournal of Medicine/A history of coronaviruses for example.
- The bullet-point sentences in "Functions" section should be organized into paragraphs based on commons themes.
Again, you can take a look at WikiJournal of Science/RIG-I like receptors and WikiJournal of Science/The TIM barrel fold as examples.
OhanaUnitedTalk page 17:33, 15 May 2023 (UTC)
Peer review 1
[edit source]
Review by Daniel Krappmann , Helmholtz Zentrum München
These assessment comments were submitted on , and refer to this previous version of the article
The summary on CARD-CC looks good and should be informative to the readers. As I don’t have much time to edit online or so, I simply suggest to add something to the section on function:
… CBM complex assembly results in recruitment of TRAF6 to MALT1 and downstream activation of NF-κB transcriptional activity and expression of pro-inflammatory cytokines (REF1). In addition, CBM complex formation activates MALT1 protease function, which modulates immune and inflammatory responses (REF2). The different CARD-CC family…
I would add these Refs for clarity:
REF1: O’Neill, T.J., T. Seeholzer, A. Gewies, T. Gehring, F. Giesert, I. Hamp, C. Graß, H. Schmidt, K. Kriegsmann, M.J. Tofaute, K. Demski, T. Poth, M. Rosenbaum, T. Schnalzger, J. Ruland, M. Göttlicher, M. Kriegsmann, R. Naumann, V. Heissmeyer, O. Plettenburg, W. Wurst, and D. Krappmann, TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease. Science Immunology, 2021. 6(65): p. eabh2095. DOI: 10.1126/sciimmunol.abh2095.
REF2: Jaworski, M. and M. Thome, The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cell Mol Life Sci, 2016. 73(3): p. 459-73. DOI: 10.1007/s00018-015-2059-z.
OhanaUnitedTalk page 18:39, 7 September 2023 (UTC)
Peer review 2
[edit source]
Review by anonymous peer reviewer , Researcher in biochemistry, proteins
These assessment comments were submitted on , and refer to this previous version of the article
As far as my knowledge goes this submission is factually correct, but little more than an ennumeration of items, smothered under an avalanche of acronyms (some of which are acronyms of acronyms). If the coiled-coil part of the proteins mediates oligomerization, why are the proteins shown as monomers in Figure 1? I know that the structures in Figure 1 are AlphaFold models taken from AlphaFold-DB, but their helices are too far apart to form coiled coils in the monomeric state. They would form coiled coils if their structure was computed at the correct oligomer state. I have no idea what that is.
OhanaUnitedTalk page 20:25, 23 April 2025 (UTC)
Peer review 3
[edit source]
Review by Iva Hafner-Bratkovič , National Institute of Chemistry, Slovenia
These assessment comments were submitted on , and refer to this previous version of the article
Jens Staal presents a nice short overview about the evolution of CARD-CC protein family and the function of these proteins in health and disease. My only comment is that references can be slightly updated (e.g. for CARD11 PMIDs 39743591, 30170123).