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Progress and Prospects in Parkinson's Research/Symptoms/M - N

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The A-Z of Parkinson's Symptoms

M

Mad Hatter's Disease

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Erethism

Pathological irritability or sensitivity of an organ or a body part.

This symptom (also known as Mad Hatter's Disease is commonly associated with mercury toxicity, (prevalent in hat manufacture) which is itself a noted causal risk for PD.

The following references are relevant:-

Critchley (1981) Speech disorders of Parkinsonism: a review. [1]

Clarkson et al (2003) Human Exposure to Mercury: the Three Modern Dilemmas [2]

Liu et al (2012) Occupational Neurotoxic Diseasesin Taiwan[3]

Further Research

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References

  1. ↑ Critchley, E.M. (1981) Full Text J. Neurol. Neurosurg. Psychiatry 44 (9) 751 – 758. Spech disorders of Parkinsonism: a review http://www.ncbi.nlm.nih.gov/pmc/articles/PMC491132/
  2. ↑ Clarkson, Thomas W.; Magos, Lazio and Myers, Gary J. font color="maroon">(2003) Abstract The Journal of Trace Elements in Experimental Medecine. 15 321 – 343 Human Exposure to Mercury: the Three Modern Dilemmas http://onlinelibrary.wiley.com/doi/10.1002/jtra.10050/abstract
  3. ↑ Liu, Chi-Hung, Huang, Chi-Yun and Huang, Chin-Chang (2012) Abstract Safety and Health at Work 3 94) 257 – 267 Occupational Neurotoxic Diseasesin Taiwanhttp://synapse.koreamed.org/search.php?where=aview&id=10.5491/SHAW.2012.3.4.257&code=0193SHAW&vmode=FULL
Masking

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Amimia[1]

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Fixed and vacant expression (masking)

Very little research has been carried out on this common PD symptom but the following are relevant :-

Allen (1931) The Dissociation of voluntary and emotional movements of the face with special reference to emotional paresis as a physical sign [2]

Hemmesch et al (2009)The Influence of Facial Masking and Sex on Older Adults’ Impressions of Individuals with Parkinson’s Disease. [3]

Clark et al (2011) Visual Exploration of Emotional Facial Expressions in Parkinson's Disease [4]

Tickle-Degnen et al (2011) Culture, Gender and Health Care Stigma: Practitioners’ Response to Facial Masking Experienced by People with Parkinson’s Disease < [5]

Further Research

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Literature search:

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References

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  1. ↑ http://medical-dictionary.thefreedictionary.com/
  2. ↑ Allen, I.M.(1931) Full Text The Dissociation of voluntary and emotional movements of the face with special reference to emotional paresis as a physical sign http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1038785/?page=1
  3. ↑ Hemmesch. Amanda R.; Tickle-Degnen, Linda and Zebrowitz, Leslie A. (2009) Full Text Psychol. Aging 24 (3) 542 – 549 The Influence of Facial Masking and Sex on Older Adults’ Impressions of Individuals with Parkinson’s Disease. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761205/
  4. ↑ Clark, Uraina S.; Neargarder, Sandy and Cronin-Golomb, Alice (2011) Full Text Visual Exploration of Emotional Facial Expressions in Parkinson's Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876199/
  5. ↑ Tickle-Degnen, Linda and Zebrowitz, Leslie A. and Ma, Hui-ing (2011) Full Text Soc. Sci. Med. 73 (1) 95 – 102 Culture, Gender and Health Care Stigma: Practitioners’ Response to Facial Masking Experienced by People with Parkinson’s Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142938/
Micrographia

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Micrographia

Microscopic handwriting

The following references are relevant:-

Oliveira et al (1997) Micrographia in Parkinson's disease: the effect of providing external cues [1]

Dounskaia et al (2009) Biased Wrist and Finger Coordination in Parkinsonian Patients during Performance of Graphical Tasks [2]

Shukla et al (2012) Micrographia and related deficits in Parkinson's disease: a cross-sectional study [3]

Further Research

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Literature search:

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Micrographia Pubmed (abstracts)
Micrographia Pubmed_Central (Full_Text)
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References

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  1. ↑ Oliveira, R.; Gurd,J.; Nixon, P.; Marshall, J. and Passingham, (1997) Full Text R. J. Neurol. Neurosurg. Psychiatry. 63 (4) 429 – 433.Micrographia in Parkinson's disease: the effect of providing external cueshttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169751/
  2. ↑ Dounskaia, Natalie; Van Gemmert, Arend W,A. ; Leis, Berta C. and Stelmach, George A. (2009) Full Text Neuropsychologia 47 (12) 2504 – 2514. Biased Wrist and Finger Coordination in Parkinsonian Patients during Performance of Graphical Tasks http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712583/
  3. ↑ Shukla, Aparna Wagle; Ounpraseuth, Songthip; Gray, Vickie; Schwankhaus, John; and Metzer, walter Steven (2012) Full Text BMJ Open. 2 (3): e000628. Micrographia and related deficits in Parkinson's disease: a cross-sectional study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383984/
Motor fluctuations

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Motor fluctuations

'On-off' periods, wearing off, dose failures, and freezing associated with long-term levodopa use

The following references are relevant:-

Bordelon et al (2011) Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease [1]/

Bohnen et al (2011) Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease [2]

Mera et al (2012) Feasibility of home-based automated Parkinson’s disease motor assessment [3]

Further Research

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Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Motor_fluctuations.
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References

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  1. ↑ Bordelon, Yvett;M.; Hayes, Ron D,; Vassar, Stefanie D.; Diaz, Natalie; Bronstein, Jeff and Vickrey, Barbra, G. (2011) Full Text Parkinsons Dis. 2001 967839 Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236449
  2. ↑ Bohnen, Nicolaas I.; Muller, Martijn L.T.M.; Zarzhevsky, Natalia; Koeppe, Robert A.; Bogan, Christopher W.; Kilbourn, Michael R.; Frey, Kirk A. and Albin, Roger L.(2011) Full Text Brain 134 (8) 2358 – 2365 Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155702/
  3. ↑ Mera, Thomas O.; Heldman, Dustin (2012) Full Text J. Neurosci. Methods 203 (1) 152 – 156. Feasibility of home-based automated Parkinson’s disease motor assessment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221741/
Mydriasis (Dilated pupils)

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Mydriasis

Dilated pupils.

The following references are relevant:-

Bitsios et al (1998) Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man [1]

Mojunder and Wensel (2009) Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice [2]

Armstrong (2011) Visual Symptoms in Parkinson's Disease [3]

Further Research

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Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Mydriasis.
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References

  1. ↑ Bitsios, P.; Langley, R.W.; Tavernor, S.; Pykko, K.; Scheinin, M; Szabadi, S. and Bradshaw, C.M. (1998) Full Text Br. J. Clin. Pharmacol. 45 (6) 551 – 558. Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1873648/
  2. ↑ Mojunder, Deb Kumr and Wensel, Theodore G.; (2009) Full Text Invest. Ophthalmol. Vis. Sci. 51 (1) 567 – 576. Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869068/
  3. ↑ Armstrong, R.A. (2011) Full Text Parkinsons Dis.; 2011: 908306. Visual Symptoms in Parkinson's Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109513/
Myoclonus(Sudden unexpected jerks)

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Myoclonus

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Sudden violent jerks.

The following references are relevant:-

Mera et al (2011) Feasibility of home-based automated Parkinson’s disease motor assessment [1]

Lanska (2010) Chapter 33: the history of movement disorders [2]

Kojovic et al (2011) Myoclonic disorders: a practical approach for diagnosis and treatment [3]

Further Research

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Search the scientific literature

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Myoclonus.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
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References

[edit | edit source]
  1. ↑ Mera, Thomas O.; heldman, Dustin A; Epay, Albert J. ; Payne, Megan and Giuffrida, Joseph P. (2011) Full TextJ. Neurosci. Methods 203 (1) 152 – 156. Feasibility of home-based automated Parkinson’s disease motor assessment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221741/
  2. ↑ Lanska, D.J. (2010) Full Text Handb. Clin. Neurol. 95:501-46. Chapter 33: the history of movement disorders http://www.ncbi.nlm.nih.gov/pubmed/19892136
  3. ↑ Kojovic, Maja; Cordivari, Carla and Bhatia, Kailash (2011) Full Text Ther. Adv. Neurol. Disord. 4 (1) 47 – 62. Myoclonic disorders: a practical approach for diagnosis and treatment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036960/

N

Narcolepsy

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Narcolepsy Sudden urge to sleep.

The following references are relevant:-

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978248/

http://www.ncbi.nlm.nih.gov/pubmed/22747735

http://www.ncbi.nlm.nih.gov/pubmed/22939103


Further Research

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Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Narcolepsy.
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References


< Back to Parkinson's Symptoms

Links to the symptoms of Parkinson's in alphabetical order:

A B C D E
F - G H I - L M - N O
P - Q R S T U - Z

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