Motivation and emotion/Book/2015/Menstrual cycle and emotion

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Menstrual cycle and emotion:
How and why do emotions vary during the menstrual cycle?


“Women complain about premenstrual syndrome, but I think of it as the only time of the month that I can be myself.”
― Roseanne Barr)

The menstrual cycle is something that the majority of people have experienced either directly or indirectly. Whilst men do not have a menstrual cycle, it is highly likely that they have been bystanders whilst a significant female (e.g., girlfriend, sister or wife) have dealt with the associated variables and consequences. The changes in emotion and mood associated with the menstrual cycle have frequently been stereotyped in Westernised society.

A common reoccurring perception of the emotions, paints women to be: crazy, irrational and emotional throughout their menstrual cycle. A quick google search of "girls on their period" provides a multitude of results, ranging from: memes which aim to make light of the subject, YouTube videos demonstrating how "girls act" during the menstrual cycle (click here to view an example), informative articles explaining what is occurring during the menstrual cycle and some inaccurate articles. An analysis of research conducted by Romans, Clarkson, Einstein, Petrovic & Stewart (2012) looked at a variety of research and concluded that there is no consistent information to support or discredit the existence, cause and prevalence of emotion and mood based changes during the menstrual cycle.

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Chapter goals

  • Explain the menstrual cycle process
  • Explain "How" and "Why" emotions vary during the menstrual cycle
  • Discuss theory and research relating to emotion and mood
  • Suggest treatments for emotion/mood flactuation

Menstrual cycle[edit]

Figure 1. Diagram of the human menstrual cycle

The menstrual cycle occurs when a woman reaches puberty and becomes fertile (Oertelt – Prigione, 2012). Oertelt – Prigione (2012) also explained that the purpose of the menstrual cycle is to prepare the woman for the conception of a child. The average menstrual cycle lasts for a period of 28 days. Day one of the cycle occurs when the menstrual flow begins and ovulation usually occurs at day 14 (Talbi, et al., 2005). The menstrual cycle consists of three phases:

  • Menstrual Phase (Day 1 to 5)
  • Follicular Phase ( Day 6 to 14, with ovulation occurring at day 14)
  • Luteal Phase (Day 15 to 28) (Levay & Valente, 2006).

Figure 1. Shows the pattern of hormonal change throughout the average menstrual cycle and the endometrial histology.

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How much do you already know


What is the average onset of menstruation?

12 - 16 years
7 - 17 years
21 - 24 years
8 - 13 years
none of the above


A woman will spend on average ______ days menstruating in her lifetime



Women are born with all the ova that they will ever have.



Figure 2. Examples of emotions

Emotions are a difficult construct to define; however, it is considered that the best definition is a blend of mental and behavioural aspects which include: appraisal, action tendency, subjective experience, physiological reactions, facial and vocal expression elements (Reisenzai, 2007).

Affect, feelings, and mood are often used in the same context without a clear distinction between the various terms (Shouse, 2005).

  • Affect is an abstract idea that can be described as: “ a non-conscious experience of intensity; it is a moment of unformed and unstructured potential” (Shouse, 2005).
  • Mood can be defined as: “A continued emotional state that affects one’s outlook on life.” (Sikora, 2011).
  • Feelings can be defined as: experiences that are references against our past experiences and are categorised based on previous knowledge (Shouse, 2005).


The affective phenomenon relates to the combined study of emotions, moods and affect. Historically these terms have been used interchangeably and efforts to distinguish between the various terms have only occurred in the recent years (Ekkakkis, 2012).

Theory and research[edit]

'The "how" and "why" of emotional change throughout the menstrual cycle is not clear. Research and theory is inconclusive as to the cause of the changes as well as the reasons for the change in emotion.

Menstrual cycle disorders[edit]

Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are two mood disorders that appear to be linked to the hormonal changes that occur throughout the menstrual cycle (Freeman, 2007). However, research is inconclusive in terms of the overall relationship between the menstrual cycle and associated mood disorders (Romans et al. 2012).

PMS is the disorder that is utilised to explain the symptoms that women experience during the week prior to the menstrual phase of their menstrual cycle (Reilly & Kremer, 2001). PMS has a range of physical and psychological symptoms which may include the following (MayoClinic, 2015):

  • tension
  • anxiety
  • depressed mood
  • crying spells
  • fatigue
  • acne

The cause of PMS is undetermined, hormones may play a role and chemical changes in the brain may also be an influencing factor. (MayoClinic, 2015).

PMDD is a more severe form of PMS, that is also defined in The Diagnostic and Statistical Manual of Mental Disorders (DSM). The DSM IV - TR defines the symptoms of PMDD as: a significant depressed mood, high levels of anxiety and marked affective lability. PMDD differs from PMS in that the changes in mood are extreme (Gallenberg, 2012).

According to the DSM IV - TR the diagnosis for PMDD requires that the above-mentioned symptoms be present during the final week of the luteal phase (for a minimum of one year); the symptoms ease during the initial week of menses; and the symptoms are non-existent in the following week. The other criteria for the diagnosis include a range of symptoms (see table 1), of which the individual has to display a minimum of five, for a majority of the luteal phase.

Table 1.DSM IV - TR diagnostic criteria for PMDD

Psychological feeling Physiological
sad, hopeless or depreciating change in appetite
tense, anxious or 'on edge' hyper insomnia or insomnia
marked lability of mood tearfulness
irritability, anger or increased conflict cramps, breast tenderness
difficulty concentrating bloating and/or weight gain.
fatigued or lethargic joint or muscle pain

Biological and physiological explanations[edit]

Biorhythm theory[edit]

The idea of emotions being related to a 28 day cycle was initially proposed in the form of Fliess’ Biorhythm Theory (Shermer, 2002). The theory was based on the premise that humans have three cycles that occur monthly: a physical cycle lasting 23 days; an emotional cycle lasting 28 days; and an intellectual cycle lasting 33 days. It is thought that the 28 day emotional cycle idea was related to the menstrual cycle (Shermer, 2002. & Hines 1998). The Biorhythms were developed to assist with predicting why humans experience highs and lows depending on the particular day (Cavendish, 2010). A review of the research for the Biorhythm Theory has been unsuccessful in verifying its validity[factual?]. Consequently the Biorhythm Theory is often referred to as a pseudo-theory without any scientific proof (Hines, 1998).

Hormones and the menstrual cycle[edit]

Figure 3. Diagram of the endocrine system

The menstrual cycle is a repetitive process which is dictated by the changes of the levels of various hormones in the body. The specific hormones are produced and controlled by the: hypothalamus, pituitary glands and the ovaries. The three areas form a part of the endocrine system (Popat, Prodanov, Kalis & Nelson, 2008). The three areas of the endocrine system produce and control the specific hormones that are necessary for menstruation to occur (Babycentre, 2015 & Brzyski & Knudston, 2015).These hormones are also associated with a range of emotionally and mood based aspects as shown in Table 2.

Table 2.
Menstrual cycle hormone function

Hormone Location Function Association to emotion and/or mood
Gonadotrophin-releasing hormone (GnRh) Brain (Hypothalamus) Stimulation of body to release Follicle-stimulating hormone and Luteinizing hormone Use of GnRh agonists is limited (due to high cost) however the available research has found that PMS symptoms ease with the use of GnRh agonists. With further research suggesting that GnRh agonists are a potential solution to easing disorders caused by oestrogen. (Kumar & Sharma 2014 ; Warnock, Burden & Morris 1998).
Follicle-stimulating hormone (FSH) Pituitary Gland (in the brain) Responsible for the ripening of ovum Low FSH levels are associated with various menstrual cycle disorders including infertility and ovarian failure. These issues may present in the form of mood swings and depression (Serge, 2014).
Luteinising Hormone (LH) Pituitary Gland (in the brain) Stimulates ovaries for the release of ovum It is suggested that a decrease in oestrogen levels combined with an increase in LH, may be associated with mood disorder occurrences in perimenopausal and menopausal women (Steiner, Dunn, Born, 2003).
Oestrogen Ovaries Stimulates and prepares body for potential conception Oestrogen is related to mood in terms of it's capacity to increase serotonin in the body. However, high levels of oestrogen may lead to anxiety and irritability and low levels may lead to depression (Integrative Psychiatry, 2015).
Progesterone Ovaries Stimulates and prepares body for potential conception Progesterone is said to ease anxiety and depression as well as assist with the increase of serotonin (Integrative Psychiatry, 2015; NatureOne, 2015). However, an excessive amount of Progesterone is said to be associated with the increase of cortisol in the body (Scott, 2012).

The changes of hormones throughout the menstrual cycle are said to be directly related to the changes in mood (Schwartz, Romanis, Meiyappan, Souzal & Einstein, 2012). Various studies have looked at the effects of hormonal changes throughout the menstrual cycle and the implications for mood and emotional change and the results are inconclusive:

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"Yes" menstrual cycle hormones do affect emotion and mood:

  1. Payne (2003) - Conducted a literarture review in relation to the effects of estrogen on mood. The results concluded that whilst not all women demonstrate hormonally stimulated depressive symptoms, there is a group of women that have mood changes directly related to the changes of hormones.
  2. Ossewarde, Hermans, Wingen, Kooijman, Johannson, Backstrom & Fernandez (2010) - Utilised a crossover study design to investigate the changes during the luteal and follicular stages. Their results concluded that: changes during the menstrual cycle play a role in the emotional regulatory circuit and are additionally influenced by stress. Their results also concluded that the luteal phase was related to negative emotions and that heart rate was higher during stress induced situations.

"No" menstrual cycle hormones do not affect mood or emotion

  1. Van Goozen, Wiegant, Endert, Helmond & Van de Poll. (1997) — Investigated mood changes in relation to hormonal changes throughout the menstrual cycle for a group of participants. The study utilised a combination of blood tests to test hormone levels and self-report assessments to measure mood. The researchers found a pattern for the change in the levels of oestrogen, progesterone and androgenic hormones. However, they did not find any pattern in the changes in relation to mood - depression, tension, anger or fatigue. Consequently the results of this study do not support the ideology that hormonal variations throughout the menstrual cycle are casual, or in this case even correlated to mood alteration.
  2. Schwartz, Romanis, Meiyappan, Souzal & Einstein (2012)— Looked at ovarian hormone levels by measuring them directly and comparing the hormone changes to mood change. Their results concluded that hormone levels were not correlated to moods. The study established that the individual’s interpretation of their stress levels and overall physical health were proven to be a more reliable predictor of mood than the hormone levels.

Psychological explanations[edit]

[Provide more detail]

Social Learning Theory (SLT)[edit]

Figure 4. Reciprocal determinism presented in context of the Social Learning Theory

The social learning theory focuses on behaviour in terms of learning and is dictated by the outcomes of the behaviour. Bandura (1971) explained that: people learn by observing the behaviour of others and we perform actions that achieve a desired outcome. We are also likely to continue a behaviour if we receive reinforcement that is beneficial to us (Bandura, 1971).

It is suspected that the SLT may play a crucial role in the development of Premenstrual Syndrome (PMS). Scalise (2007) suggested that women develop a negative attitude in regard to their menstrual cycle and as a consequence they develop coping mechanisms such as overeating and mood swings. A study conducted by Woods, Mitchell and Lentz (1995), looked at the effect of social influence in terms of how an individual responds to their menstrual cycle. The researchers looked at three classes of symptoms: low severity (LS); premenstrual syndrome (PMS); and premenstrual magnification (PMM). Their results were consistent with the social learning theory, such that women who anticipated negative symptoms and reported being socially primed to expect negative symptoms throughout the menstrual cycle were more likely to report these negative symptoms. The researchers concluded that stressful experiences and social priming of negative menstrual symptoms might enforce the negative connotation relating to their menstruation (Woods, Mitchell & Lentz, 1995).


According to the SLT, emotional changes during the menstrual cycle occur because of the social expectation that they will. For example if Anna's mum displayed severe mood swings throughout the month, which she attributed to the menstrual cycle, then Anna is likely to copy her mum's behaviour and behave in a similar manner. Moreover, if the behaviour led to a reward such as chocolate then Anna may perform the specific behaviour in the hope that she will also receive chocolate.

Cognitive theory[edit]

Cognitive attribution is important in the aetiology of PMS. According to cognitive theory, both physical symptoms and the meaning of these symptoms induce distressing emotions (Blake, Salkovskis, Gath, Day & Garrod, 1998). Therefore, when a woman feels sad, irritable or angry she may find these emotions more distressing if she attributes them to bodily functions out of her control (i.e. menstruation). In taking this view, distorted thinking is an important component of PMS, generating psychological and physiological upset (Blake et al., 1998). Blake et al. (1998) found cognitive therapy (CT) significantly improved PMS and depressive symptoms in women previously diagnosed with PMS.

Likewise, meta-analysis by Kleinstäuber, Witthöft and Hiller (2012) revealed small to medium effects for efficacy of CBT as treatment for PMS. Symptom-reduction was maintained for longer following psychotherapy compared to pharmacotherapy, possibly due to side effects associated with the latter (Kleinstäuber et al., 2012). Whilst cognitions appear to play a role in women’s experience of PMS, associated mood fluctuations cannot be explained by biological or psychological theory alone. Rather, an integrated approach best accounts for observed emotional variations. 

Interpreting emotions during the menstrual cycle[edit]

[[File:MRI Location Amygdala up.png|175x175px|thumb|left|alt=MRI coronal view of the amygdala|Figure 5. MRI coronal view of the amygdala

Derntl et al. (2008) conducted a study looking at emotion recognition in females during both the follicular phase (FPG) and the luteal phase. The study utilised a series of images that depicted various emotions. The participants were then asked to pick from two options in order to correctly identify the emotion that was presented to them. They measured the activation of the amygdala throughout the experiment, utilising echo-planar imaging (EPI). Derntl and colleagues (2008) concluded that amygdala activation occurred in both the FPG and luteal phase groups, with the FPG demonstrating a higher amygdala stimulation. Moreover, the results of the study concluded that women in the FPG phase demonstrated a better capacity in recognising emotions in comparison to the luteal phase group.

Further research conducted by Derntl, Exner, Fernbach, Moser & Habel (2008) also concluded that the correct identification of emotions was the most reliable during the follicular phase. The researchers also found that lower progesterone levels were related to higher accuracy when identifying emotions. Moreover, females in the luteal phase were more likely to misinterpret emotions that were negative as being angry. The correlation between levels of estradiol and progesterone were significant in relation to the identification of anger, with females in the luteal phase showing higher inaccuracies when interpreting emotions (Derntl, Exner, Fernbach, Moser & Habel, 2008).

Treatment options[edit]

Crocus Sativus (Saffron)
Figure 6. Picture of Golden Saffron

A randomised trial that utilised a placebo and experimental sample was conducted by Hosseini, Kashani, Aleyaseen, Ghoreishi, Rahmanpour, Zarrinara & Akhondzaden (2007) to assess the efficacy of saffron as a treatment for PMS. The participants in the experimental group were given two tablets per day (30mg total), which were made from saffron petals. The results were tracked over a period of two menstrual cycles for both the experimental and control group. The premise of the study was based on previous research that had concluded that saffron acts as an anti-depressant by the means of the serotonergic system (Hosseini et al. 2007). This study provided further support for the use of Saffron in the treatment for PMS, with the experimental group displaying statistically significant positive changes in their depressive mood (Hosseini et al. 2007).

Drug treatments
Figure 7. Oral contraceptive

A study conducted on a sample of 1600 women, found that the treatment group that utilised a drospirenone and estradiol contraceptive pill showed reduced signs of PMS when compared to the placebo group after three months of use (Lopez, Kpatein, Helmerhorst, 2009). Further research conducted by Zervoudis, Vladareanu, Galazios, Liberis, Tsikouras and Veduta (2008) concluded that the use of an oral contraceptive was 67.9% more effective at treating PMS when compared to a baseline group.

Hypnosis and CBT

Typical medication treatments have been compared with alternative treatment methods such as cognitive behavioural therapy (CBT) and hypnosis. Rasht and Sari (2015) found that over a 8 week period implementation of CBT and combination of CBT and hypnosis - patients demonstrated a reduction in reported pain (p < 0.001). Further research found a decrease in anxiety prior to expected menstruation period. Group therapy was also found to reduce fear emotions prior to menstruation periods (Glover, Jovanovic, & Norrholm, 2015). Post-traumatic stress disorder (PTSD) treatment demonstrated efficacy in separating fear response with the increased presence of oestrogen in a female’s system.


The menstrual cycle is a complex sequence of events strongly based on hormonal change, there is no single correct answer that can explain "why" and "how" emotions change.The research of the causal factors of the menstrual cycle emotion change is inconclusive. The two key explanations relate to the hormonal changes, such that emotions change due to the fluctuation of hormones. The secondary explanation revolves around the idea that emotions vary throughout the menstrual cycle due to social aspects. You can find further Applied examples on this page.

The reasons provided for the explanation of emotion change vary depending on the research. With a significant amount of discrepancy in the results further research may be conducted to explore why these inconsistencies have transpired. Future research may also be conducted in terms of emotional changes in males and females as a comparison to investigate whether females tend to have more fluctuations in terms of the emotional change. Moreover, research may also be conducted to assess the impact of external events on emotion and mood.

Various treatments have been found to be successful in assisting with emotion control. The external links provides further articles that may be of interest in terms of providing alternate treatment options.

This book chapter does not aim to offer a solution and should never substitute a health care professionals advice. If you need someone to talk to you can contact Lifeline on 13 11 14.

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Test yourself


According to the social learning theory, what is a possible explanation for Premenstrual syndrome?

the hormonal changes that occur during the menstrual cycle
something similar to stress
the symptoms of premenstrual syndrome can all be attributed to genetics
social factors such a watching other people's behaviour may influence the likelihood and intensity of premenstrual syndrome
premenstrual syndrome is fake and made up by social scientists.


The biorhtym theory suggested that emotions rotate on a 28 day cycle?



A study conducted by Derntl et al. (2008) found that:

when viewing emotions, females in the luteal phase were most accurate in determining the presented emotion
the amygdala is not activated at all when viewing various emotion based stimuli
women in the luteal phase were more efficient and accurate in identifying emotions and that the amygdala was activated in both the luteal phase and follicular phase.
women in the follicular phase were more efficient and accurate in identifying emotions and that the amygdala was activated in both the luteal phase and follicular phase.


The Gonadotrophin-releasing hormone is responsible for the stimulation of follicle-stimulating hormone and is located in the brain.



Type your answer in the text box below

Saffron has been found to be an

treatment for emotion/mood based issues

See also[edit]


American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: Author.

Babycentre (2015).  How your menstrual cycle works. Retrieved from:

Bandura, A. (1971). Social Learning Theory. Retrieved from:

Blake, F., Salkovskis, P., Gath, D., Day, A., & Garrod, A. (1998). Cognitive therapy for premenstrual syndrome: a controlled trial. Journal of Psychosomatic Research, 45(4), 307-318. doi:10.1016/S0022-3999(98)00042-7

Brzyski, R, G., & Knudston, J. (2015). Menstrual Cycle. Retrieved from

Cavendish, M. (2010). Biorhythm Theory. In Encyclopedia of Health (4th Ed). Retrieved from:

Derntl, B., Exner, K, I., Fernbach, E., Moser E, & Habel, U. (2008). Emotion recognition accuracy in healthy young females is associated with cycle phase. Hormones and Behaviour. 53 (1). Pp 90 –95. Doi:10.1016/j.yhbeh.2007.09.006

Derntl, B., Windischberger, C., Robinson, S., Lamplmayr, E., Exner, K, I., Gur, R, C., … Habel, U. (2008). Facial emotion recognition and amygdala activation are associated with menstrual cycle phase. Psychoneuroendocrinology.33(8). Pp 1031 – 1040. Doi: 10.1016/j.psyneuen.2008.04.014

Ekkakis, P. (2012) Affect, Mood and Emotion. Measurement in sport and exercise psychology. Retrieved from:

Freeman, E. W. (2007). The clinical presentation and course of premenstrual symptoms. The premenstrual syndromes: PMS and PMDD, pp 55-61. Doi: doi:10.1016/j.yhbeh.2012.08.001

Gallenberg, M, M. 2012. Premenstrual Syndrome (PMS). Retrieved from:

Glover, E. M., Jovanovic, T., & Norrholm, S. D. (2015). Estrogen and extinction of fear memories: Implications for posttraumatic stress disorder treatment. Biological Psychiatry, 78, 178- 185. doi: 10.1016/j.biopsych.2015.02.007

Hines, T, M. (1998). Comprehensive review of biorhythm theory. Psychology Report. 83 (1), pp 19 – 64. Retrieved from:

Integrative Psychiatry. (2015). Hormone Balance. Retrieved from:

Kleinstäuber, M., Witthöft, M., & Hiller, W. (2012). Cognitive-Behavioral and Pharmacological Interventions for Premenstrual Syndrome or Premenstrual Dysphoric Disorder: A Meta-Analysis. Journal of Clinical Psychology In Medical Settings, 19(3), 308-319. doi:10.1007/s10880-012-9299-y

Kumar, P. & Sharma, A. (2014). Gonadotropin-releasing hormone analogs: Understanding advantages and limitations. Journal of Human Reproductive Sciences. 7(3). Pp 170 – 174. Doi: 10.4103/0974-1208.142476

Levay, S, & Valente, S, M. (2006). Human Sexuality. (2nd edition). MA, USA. Sinauer.

Lopez, L, M., Kaptein, A, A., & Helmerhorst, F, M. (2007). Oral contraceptives containing drospirenone for premenstrual syndrome. Cochrane Database of Systematic Reviews 2. Doi: 10.1002/14651858.CD006586.pub3

MayoClinic (2015). Premenstrual Syndrome (PMS) Retrieved from:

NatureOne. (2015). Depression. Retrieved from:

Oertelt – Prigione, S. (2012). Immunology and the menstrual cycle. Autoimmunity Reviews. 11 (6 -7). Pp 486 – 492.  DOI: 10.1016/j.autrev.2011.11.023

Ossewaarde, L., Hermans, E, J., Van Wingen, G, A., Kooijman, S, C., Johansson, I, M., Backstrom, T., & Fernandez, G. (2010). Neural mechanisms underlying changes in stress-sensitivity across the menstrual cycle. Psychoneuroendocrinology. 35(1). Pp 47 – 55. Doi: 10.1016/j.psyneuen.2009.08.011

Payne, J. (2003). The role of estrogen in mood disorders in women. International Review Of Psychiatry, 15(3), Pp 280 – 290. Doi: 10.1080/09540260310000136893

Popat, V, B., Prodanov, T., Calis, K, A., & Nelson, L, M. (2008). The Menstrual Cycle - A Biological Marker of General Health in Adolescents.  Annals of the New York Academy of Sciences. 1 (1135), Pp 43 – 51. doi:10.1196/annals.1429.040

Rasht, I., & Sari, M. (2015). Comparison of the effectiveness of group cognitive behavioural therapy and group cognitive hypnotism for anxiety in women with premenstrual syndrome. Journal of Gulian University of Medical Sciences, 24, 58- 66. doi: 10.1526/1811

Reilly, J. & Kremer, J. (2001). PMS: Moods, measurements and interpretations. The Irish Journal of Psyhcology. 22(2). Pp 22 – 37. Doi: 10.1080/03033910.2001.10558270

Reisenzein, R. (2007). What is a definition of emotion? And are emotions mental-behavioral processes? Social Science Information. 46 (3), Pp 424 – 428. doi: 10.1177/05390184070460030110

Romans, S., Clarkson, R., Einstein, G, Petrovic, M., & Stewart D. (2012). Mood and the Menstrual Cycle: A Review of Prospective Data Studies. Gender Medicine 9(5). Pp 361 – 384. doi:10.1016/j.genm.2012.07.003

Scalise, D. (2007). The Everything Healthy Guide to PMS. Massachusetts. Adams Media.

Schwartz, H, D., Romans, S, E., Meiyappen, S., Souza, M, J, D., & Einstein, G. (2012). The role of ovarian steroid hormones in mood. Hormones and Behavior. 62(4). Pp 448 – 454. Doi: 10.1016/j.yhbeh.2012.08.001

Scott, J, A. (2012). How your menstrual cycle affects your behaviour Retrieved from:

Serge, A, J. (2014). Follicle-Stimulating Hormone Abnormalities Clinical Presentation. Retrieved from:

Shermer, M. (2002). ‪The Skeptic Encyclopedia of Pseudoscience. Body, Mind and Spirit. Retrieved from:

Shouse, E. (2005). Feeling, Emotion, Affect. A journal of media and culture. 8(6). Retrieved from:

Sikora, C. (2011). Mood. In Encyclopedia of Child Behavior and Development. Springer.

Steiner, M., Dunn, E., & Born, L. (2003). Hormones and mood: from menarche to menopause and beyond. Journal of affective disorders, 74(1), pp 67-83.

Talbi, S., Hamilton, A, E., Vo, K, C., Tulac, M, T., Overgaard, C., Dosiou, N., Shay, L., Nezhat, C, N., Kempson, R., Lessey, B, A., Nayak, N, R. & Giudice, L, C. (2005). Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women. The Endocrine Society. 147 (3). Pp 1097 – 1121. DOI: 10.1210/en.2005-1076

Van Goozen, S, H, M., Wiegant, V, M., Endert, E., Helmond, F, A., & Van de Poll, N, E. (1997). Psychoendocrinological assessment of the menstrual cycle: The relationship between hormones, sexuality, and mood. Archives of Sexual Behavior. 26(4). Pp 359 – 82. Retrieved from:

Warnock, J, K., Bundren, J, C. & Morris, D, W. (1998). Depressive symptoms associated with gonadotropin-releasing hormone agonists. Depression & Anxiety. 7(4). Pp 171 – 177.

Woods, N, F., Mitchell E, S, & Lentz, M, J. (1995). Social Pathways to Premesntrual Symptoms. Research in nursing and health. 18 (3), Pp 225 – 237.

Zervoudis, S., Vladareanu, R., Galazios, G., Liberis, V., Tsikouras, P., & Veduta, A. (2008). Oral contraceptives with and without drospirenone in the treatment of premenstrual syndrome and premenstrual dysphoric disorder. A mulitcentric study of 92 cases. Acta Endocrinologica 4(1), 47-58.

External links[edit]