WikiJournal Preprints/The effect of local millet drink (Kunu) on the testis and epididymis of adult male wistar rats

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Authors: Darlington Cyprain Akukwu[a], Godwin Chinedu Uloneme[a], Damian Nnabuihe Ezejindu[b], Princewill Sopuluchukwu Udodi[b][i]ORCID iD.svg , Ifesinachi Ogochukwu Ezejindu[b], Chukwudi Jesse Nwajagu[b], Benedict Nzube Obinwa[b], Ifechukwu Justicia Obiesie[b], Emeka Christian Okafor[b], Somadina Nnamdi Okeke[b], Doris Kasarachi Ogbuokiri[b], Ambrose Echefulachi Agulanna[b]

Darlington Cyprain Akukwu; Godwin Chinedu Uloneme; Damian Nnabuihe Ezejindu; Princewill Sopuluchukwu Udodi; Ifesinachi Ogochukwu Ezejindu; Chukwudi Jesse Nwajagu; Benedict Nzube Obinwa; Ifechukwu Justicia Obiesie; Emeka Christian Okafor; Somadina Nnamdi Okeke; Doris Kasarachi Ogbuokiri; Ambrose Echefulachi Agulanna, "The effect of local millet drink (Kunu) on the testis and epididymis of adult male wistar rats", WikiJournal Preprints, Wikidata Q104785241




Abstract

Background:

Kunu is a local beverage drink that finds its origin in the northern part of Nigeria. This study was aimed at determining the effect of the liquid drink on the epididymes, testes, sperm parameters and hormonal assay.

Methods: A total of sixteen rats were used for this study and the animals were separated into four groups of four rats each (A-D). The animals were then sacrificed and the testes and epididymes harvested and fixed in 10% formal saline. Group A were fed only rat feed and water. Groups B, C and D were fed 0.2ml, 0.9ml and 2.5ml of Kunu respectively orally using a metal cannula for a period of 21 days.

Findings: There was a significant increase (P<0.05) in the relative testicular weights of groups B, C and D as compared with those of group A. There was a significant decrease (P<0.05) in sperm count in groups B, C and D when compared to group A. There was an insignificant increase (P>0.05) in FSH in groups B, C and D when compared to group A. The histopathological findings revealed that the group B rats of 0.2ml and group C rats of 0.9ml showed epididymal tissue with moderate accumulation of spermatozoa and testicular tubules with moderate enhanced spermatogenesis. The group D rats showed well accumulated spermatozoa in the epididymal lumen and improved spermatogenesis in the testis as did group A.

Conclusion: Kunu beverage may not be used as a natural male fertility booster since it does little to improve sperm count, motility, morphology, pH and hormonal levels of FSH and testosterone.


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