Progress and Prospects in Parkinson's Research/Causes/Deficiencies/Glutathione

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Glutathione (GSH) is an antioxidant, preventing damage to important cellular components caused by |reactive oxygen species such as free radicals and peroxides. All human cells have the capability of synthesising GSH but the principal source has been shown to be the liver.


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Garrido et al [1] evaluated the effects of raising and lowering glutathione levels in rats. They found that in both cases the nigral neurons deteriorated and resulted in the development of Parkinsonian symptoms. They postulated that a glutathione imbalance might be a cause of the disease and its proper regulation might be considered as a viable therapy.

There are some current research results related to the neuroprotective effects of glutathione which should be added here.  You are invited to do the search of PubMed under Today below and summarise the relevant abstracts.  Droflet (talk) 09:24, 29 July 2012 (UTC)

Further Reading

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Zeevalk, G.D.; Manzino, L.; Sonsalla, P.K. and Bernard, L. P. Full Text Exp Neurol. 203 (2): 512–520.

Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson’s disease


Kaur, Deepinder; Donna Lee, Donna; Ragapolan, Subramanian and Andersen, Julie K. Full Text Free Radic. Biol. Med. 46(5): 593–598.

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: Implications for Parkinson's disease.

Lee, Donna W.; Kaur, Deepinder; Chinta, Shankar J.; Rajagopalan, Subramanian and Andersen, Julie K. Full Text Antioxid. Redox Signal. 11(9): 2083–2094.

A Disruption in Iron-Sulfur Center Biogenesis via Inhibition of Mitochondrial Dithiol Glutaredoxin 2 May Contribute to Mitochondrial and Cellular Iron Dysregulation in Mammalian Glutathione-Depleted Dopaminergic Cells: Implications for Parkinson's Disease


Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Glutathione.

This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.

Pubmed (abstracts)

Pubmed_Central (Full_Text)


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Glucathione (GSH),--


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  1. Garrido, Manuel; Tereshchenko, Yuliya: Zhevtsova, Zinayida; Taschenberger, Grit; Bähr and Kügler, Sebastian (2011) Full Text Acta Neuropathol. 121 (4): 475–485. Glutathione depletion and overproduction both initiate degeneration of nigral dopaminergic neurons.