Progress and Prospects in Parkinson's Research/Therapy/Neuroprotection/Vitamin E
Background[edit | edit source]
Vitamin_E is a collection of 8 fat soluble compounds found in sunflower oil and a variety of vegetables including broccoli and avocados. The recommended adult intake is 15mg. per day. It stops the production of reactive oxygen species formed when fat undergoes oxidation.
Research[edit | edit source]
Perry et al  administered massive doses of alpha tocopherol (vitamin E extract) and beta-carotene (precursor to vitamin A) to marmosets with MPTP-induced PD. This did not have any demionstrable effect on their condition.
Odunze et al  induced Parkinsonism in mice by the administration of MPTP and then measured levels of Vitamin E. Vitamin E levels in all areas of the brain rose but returned to normal within a few hours except for the substantia nigra. It was conclude that Vitamin E deficient mice were much more susceptible to MPTP toxicity than controls.
Gong et al  were fed Vitamin E for 12 weeks prior to being induced with PD by MPTP injections. Their findings were:-
Mice with elevated cerebral VE were not protected from MPTP toxicity, with DA content as an indicator. In conclusion, these findings indicate that moderate elevation of brain VE is not adequate for protecting DA-containing neurons against the toxic actions of a high dose of MPTP
Fahn,S.  administered high doses of vitamins C and E to a group of PD patients receiving concomitant amantadine and anticholinergics (but not levadopa).
The time when levodopa became necessary in the treated patients was compared to another group of patients followed elsewhere who did not receive antioxidants. The time when levodopa became necessary was extended by 2.5 years in the group receiving alpha-tocopherol and ascorbate. Results of this pilot study suggest that the progression of Parkinson's disease may be slowed by administration of these antioxidants. Controlled clinical trials using double-blind randomization techniques are required to confirm these results.
Fernandez- Calle et al  compared serum levels of vitamin E between PD cases and controls and found no difference. They concluded that serum levels of Vitamin E played no part in the pathogenesis of PD.
Lewitt  compared vitamin E intake with the onset of PD in a group if patients and concluded:-
These results suggest that serum vitamin E concentrations do not play a role in the pathogenesis of PD.
Offen et al  published the results of recent research into neuroprotecton.
We have found that the thiol containing compounds, reduced glutathione (GSH), N-acetyl-cysteine (NAC), and dithiothreitol (DTT) were markedly protective, while vitamins C and E had lesser or no effect. The thiol antioxidants and vitamin C but not vitamin E, prevented dopamine autooxidation and production of dopamine-melanin.
Morens et al  compared Vitamin E intake with incidence of PD. Their findings:-
these preliminary data do not conclusively document a beneficial effect of dietary vitamin E on PD occurrence
Lan and Jiang  worked with MPTP Parkinson induced mice and found that:-
(1) iron may induce neuronal damage and thus excessive iron in the brain may contribute to the neuronal loss in PD; (2) iron chelators and antioxidants (Vit E) may serve as potential therapeutic agents in retarding the progression of neurodegeneration.
Roghani and Behzadi  worked with Parkinsonian rats and found that repeated intramuscular administration of vitamin E exerts a rapid protective effect on the nigrostriatal dopaminergic neurons in the early unilateral model of PD.
Zhang et al  set out to examine the associations between intakes of vitamins E and C, carotenoids, vitamin supplements, and risk of PD. They assembled data for 76,890 women who were monitored for 14 years, and 47,331 men who were monitored for 12 years. 371 cases of PD were recorded. Their conclusions were:-
Use of vitamin supplements and high intake of carotenoids do not appear to reduce the risk of PD. The reduction in risk of PD associated with high dietary vitamin E intake suggests that other constituents of foods rich in vitamin E may be protective. Alternatively, moderate amounts of vitamin E may reduce risk of PD, but this benefit may be lost with higher intakes.
Etminan et al  evaluated the results of 8 previous epidemiological studies and concluded that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. The studies did not suggest any protective benefits associated with vitamin C or beta carotene.
We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.
Further Reading[edit | edit source]
Bier, Ethan Full Text Proc. Natl. Acad. Sci. U S A. 103(36): 13269–13270.
Antioxidants put Parkinson flies back in the PINK.
Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Vitamin_E.
This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.
Related pages[edit | edit source]
- Substances with possible neuroprotective properties:
- Caffeine,--Celastrol,--Co-Enzyme Q10,--Creatine,--DHA,--Exendin-4 (EX-4),--GDNF,--Glutathione (GSH),--GM1,--Isradipine,--Melatonin,--Minocycline,--Nicotine,--NSAIDs,--Phenylbutyrate,--Phytic Acid,--Probucol,--Quinoxaline,--Rasagiline,--Riboflavin,--Statins,--Tolcapone,--Urate & Uric Acid,--Vitamin D,--Vitamin E,--
References[edit | edit source]
- Perry T. L.; Yong, V. W.; Hansen, S.; Jones, K.; Bergeron, C.; Foulks, J. G. and Wright, J. M. (1987) Abstract J. Neurol. Sci. 81 (2-3) 321 – 331 Alpha-tocopherol and beta-carotene do not protect marmosets against the dopaminergic neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.http://www.ncbi.nlm.nih.gov/pubmed/3121800
- Odunze, I, N.; Klaidman, L. K. and Adams, J. D. Jr. (1990) Abstract Neurosci. Lett. 108 (3) 346-9 MPTP toxicity in the mouse brain and vitamin E.http://www.ncbi.nlm.nih.gov/pubmed/2304652
- Gong, L.; Daigneault, E. A.; Acuff, R. V. and Kostrzewa, R. M. (1981) Abstract Neuroreport. 2 (9):544 - 546. Vitamin E supplements fail to protect mice from acute MPTP neurotoxicity. http://www.ncbi.nlm.nih.gov/pubmed/1751810
- (1992) Abstract Ann. Neurol. 32 Suppl: S128-32. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease. http://www.ncbi.nlm.nih.gov/pubmed/1510371
- Férnandez-Calle, P.; Molina, J. A.; Jiménez-Jiménez, F. J.; Vázquez, A.; Pondal, M.; García-Ruiz, P, J.; Urra, D. G.; Domingo, J. and Codoceo, R.(1992) Abstract Neurology 42 (5) 1064 – 1066 Serum levels of alpha-tocopherol (vitamin E) in Parkinson's disease.http://www.ncbi.nlm.nih.gov/pubmed/1579230
- Lewitt J. (1994) Abstract Neural Transm. Suppl. 43:171-81. Long-term selegiline and alpha-tocopherol treatment.http://www.ncbi.nlm.nih.gov/pubmed/7884399
- Offen, D.; Ziv, I.; Sternin, H.; Melamed, E. and Hochman, A. (1996) Abstract Exp. Neurol. 14 (1) 32 – 39, Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.http://www.ncbi.nlm.nih.gov/pubmed/8797665
- Morens, D. M. Grandinetti, A.; Waslien, C. I.; Park, C. B.; Ross, G. W. and White, L. R. (1996) Abstract Neurology. 46 (5):1270 - 1274. Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake.http://www.ncbi.nlm.nih.gov/pubmed/8628465
- Lan, J and Jiang, D. H. (1997)Abstract J. Neural. Transm. 469 -481 Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice.http://www.ncbi.nlm.nih.gov/pubmed/9295179
- Roghani, M. and Behzadi, G. (2001)Abstract Brain Res. 892 (1) 211-217 Neuroprotective effect of vitamin E on the early model of Parkinson's disease in rat: behavioral and histochemical evidence http://www.ncbi.nlm.nih.gov/pubmed/11172767
- Zhang, S. M.; Hernán, M. A.; Chen, H.; Spiegelman, D.; Willett, W. C. and Ascherio, A. (2002) Abstract Neurology 59 (8) 1161 -1160. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. http://www.ncbi.nlm.nih.gov/pubmed/12391343
- Etminan, M.; Gill, S.S and Samil, A. (2005) Abstract Lancet Neurol. 4 (6) 362 - 365 Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis.http://www.ncbi.nlm.nih.gov/pubmed/15907740