Talk:OToPS/LAMS

Links to working documents off-Wiki

Here are several working documents and folders that are Off-Wiki.

Note that data files themselves are kept secure and should not be linked directly to Wiki, but the source documents for data collection, citations for the methods, and meta-data (codebooks, scoring syntax, list of publications from data) all are things that could be linked here over time.

OSF.io Component with Copies of Measures, codebooks, and other meta-data

Draft spreadsheet versions of codebook:

• LAMS Polypharmacy paper version (Kowatch et al.)

Here's a link that will search PubMed for all articles that list the LAMS grant as a source of support. This is not exactly the same thing as the set of papers that used the data, but the results overlap a lot.

• As an aside, here's an R package that will work with PubMed search results.
• Similar package for working with GoogleScholar (but vignettes assume that you know the GoogleScholar ID)

Eyoungstrom (discuss • contribs) 04:06, 23 July 2023 (UTC)

Annotated bibliography of publications using LAMS data

n.b., Annotation only current through end of 2018; should be updated.

Here's a link that will search PubMed for all articles that list the LAMS grant as a source of support. This is not exactly the same thing as the set of papers that used the data, but the results overlap a lot.

2018

Jo, B., Findling, R.L., Hastie, T., Youngstrom, E.A., Wang, C.P., Arnold, L.E., Fristad, M.A., Frazier, T.W., Birmaher, B., Gill, M.K., & Horwitz, S.M. (2018). Construction of longitudinal prediction targets using semi-supervised learning. Statistical Methods in Medical Research, 27(9), 2674-2693. doi: 10.1177/0962280216684163.

This paper focuses on using machine learning to develop a prognostic model to categorize patients into different diagnostic groups. The authors used data from the LAMS study to develop

a prognostic model that predicts patients’  long-term manic symptom trajectory type. Through the utilization of clinical thresholds and empirical model fitting to form predictor targets, the

authors used longitudinal data from the LAMS study to improve the outcome of machine learning models.

Rizvi, S. H., Salcedo, S., Youngstrom, E. A., Freeman, L. K., Gadow, K. D., Fristad, M. A., Birmaher, B., Kowatch, R. A., Horwitz, S. M., Frazier, T. W., Arnold, L. E., Taylor, H. G., & Findling, R. L. (2018). Diagnostic accuracy of CASI-4R psychosis subscale for children evaluated in pediatric outpatient clinics. Journal of Clinical Child and Adolescent Psychology. doi: 10.1080/15374416.2017.1410824

This study sought to determine the diagnostic efficiency of the CASI-4R parent and teacher psychosis subscales using receiver operating characteristic (ROC) analysis. Participant data was derived from the LAMS study baseline assessment. After comparing parent and teacher subscale performance, the ROC analysis revealed that the CASI-4R parent report was significantly better at identifying pediatric psychotic symptoms. It is important to note that the CASI-4R is a proprietary measure, which reduces its common use in clinical settings due to the cost.

Salcedo, S., Chen, Y.-L., Youngstrom, E. A., Fristad, M. A., Gadow, K. D., Horwitz, S. M., … Findling, R. L. (2018). Diagnostic Efficiency of the Child and Adolescent Symptom Inventory (CASI-4R) Depression Subscales for identifying Youth Mood Disorders. Journal of Clinical Child and Adolescent Psychology : The Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53, 47(5), 832–846. https://doi.org/10.1080/15374416.2017.1280807

This paper used data from the LAMS study to determine the diagnostic and clinical efficacy of the CASI-4R depressive and dysthymia subscales for detecting pediatric mood disorders. The authors found that caregiver report was very accurate in predicting narrow mood diagnosis, though there was more significance for reporting symptom severity than symptom count. They also found that teacher report was not significantly accurate in predicting a narrow mood diagnosis. When controlling for demographics, the authors reported that the CASI-4R was better at predicting a narrow mood diagnosis in non-white participants. It is important to note that the CASI-4R is a proprietary measure, which reduces its common use in clinical settings due to the cost. This is the first study on this topic.

Van Meter, A. R., You, D. S., Halverson, T., Youngstrom, E. A., Birmaher, B., Fristad, M. A., . . . & The LAMS Group (2018). Diagnostic Efficiency of Caregiver Report on the SCARED for Identifying Youth Anxiety Disorders in Outpatient Settings. Journal of Clinical Child and Adolescent Psychology, 47(sup1), S161-S175. doi:10.1080/15374416.2016.1188698

This paper used data from the LAMS study to determine the diagnostic and clinical efficacy of the SCARED-P parent report for identifying pediatric anxiety disorders. The results demonstrated that the parent-rated SCARED-P scores were statistically accurate in identifying pediatric anxiety disorders. The authors note that the youth self-report on the SCARED is even more accurate than the parent report in identifying an anxiety disorder diagnosis and that the SCARED parent report would be more accurate if diagnoses relied only on the KSADS interview with the parent.

2017

Algorta, G.P., MacPherson, H. A., Youngstrom, E. A., Belt, C., Arnold, L. E., Frazier, T.W., Taylor, H.G., Birmaher, B., Horwitz, S.M., Findling, R.L., Fristad, M.A., & The LAMS Team (2017). Parenting stress among caregivers of children with bipolar spectrum disorders. Journal of Clinical Child and Adolescent Psychology, 1-15. doi:10.1080/15374416.2017.1280805.

This paper used data from the LAMS study to identify predictors and moderators of stress in caregivers of pediatric bipolar disorder. Major predictors of caregiver stress were found to be symptoms of child mania and anxiety and the presence of disruptive behavior disorder. Caregivers reported more parenting stress, higher rates of mania, depression, and antisocial personality disorder. Moderators included improvements in parent factors and family functioning. The results of this study emphasize the importance of assessing and evaluating parenting stress when treating pediatric bipolar disorder.

Horwitz, S.M., Storfer-Isser, A., Young, A.S., Youngstrom, E.A., Taylor, G.H., Frazier, T.W., Arnold, L.E. (2017) . Development of alcohol and drug use in youth with manic symptoms. Journal of the American Academy of Child and Adolescent Psychiatry, 56, 149-156. doi: 10.1016/j.jaac.2016.11.004.

This paper used data from the LAMS study to assess alcohol and drug use in a population of individuals with pediatric mania symptoms. Predictors of regular alcohol abuse were parental marital status, age, and sustained high mania symptoms in the first two years following the baseline. Predictors of regular drug use were parental marital status, stressful childhood life events, and a disruptive behavior disorder at baseline. However, the paper did find that individuals who were medicated for pediatric mania at baseline were at a decreased risk of of regular drug use.

Van Meter, A. R., Youngstrom, E. A., Birmaher, B., Fristad, M. A., Horwitz, S. M., Frazier, T. W., . . . Findling, R. L. (2017). Longitudinal course and characteristics of cyclothymic disorder in youth. Journal of Affective Disorders, 215, 314-322. doi: 10.1016/j.jad.2017.03.019

This paper used data from the LAMS study to investigate if a proposed research diagnostic criteria for cyclothymic disorder (RDCyc) could be quantified and validated in pediatric patients. It was found that clearly operationalize criteria for cyclothymic disorder in a distinct category of individuals with pediatric bipolar spectrum disorders and can differentiate such a diagnosis in individuals with non-bipolar diagnoses. This is important because cyclothymia is a largely ignored diagnosis, but has a high prevalence in populations with pediatric manic symptoms.

2016

Dickstein, D.P., Axelson, D., Weissman, A.B., Yen, S., Hunt, J.I., Goldstein, B.I., Goldstein, T.R., Liao, F., Gill, M.K., Hower, H., Frazier, T.W., Diler, R.S., Youngstrom, E.A., Fristad, M., Arnold, L.E., Findling, R.L., Horwitz, S.M., Kowatch, R.A., Ryan, N.D., Strober, M., Birmaher, B., & Keller, M.B. (2016). Cognitive flexibility and performance in children with threshold and subthreshold bipolar disorder. European Journal of Child and Adolescent Psychiatry. 25, 625-638. doi:10.1007/s00787-015-0769-2.

This paper used data from the LAMS study to assess neurocognitive function in a population of individuals with pediatric mania symptoms. The authors suggest that individuals with full DSM-IV duration episodes of mania or hypomania display impaired cognitive flexibility, sustained attention, and information processing for emotionally valenced words. This study is important in that it outlines possible targets of treatment or focus when treating patients with pediatric mania symptoms.

Fristad, M.A., Wolfson, H., Algorta, G.P., Youngstrom, E.A., Arnold, L.E., Birmaher, B., Horwitz, S., Axelson, D., Kowatch, R.A., Findling, R.L., Frazier, T.W., Holland, S., Phillips, M., & Taylor, H.G. (2016). Disruptive mood dysregulation disorder and bipolar disorder non-specified: Identical or fraternal twins? Journal of Child and Adolescent Psychopharmacology, 26, 138-146. doi: 10.1089/cap.2015.0062

This paper used data from the LAMS study to investigate the differences and similarities in disruptive mood dysregulation disorder and bipolar disorder not otherwise specified. When selecting for elevated symptoms of mania, the results suggest that pediatric disruptive mood dysregulation disorder and pediatric bipolar disorder not otherwise specified are very similar on most levels, except for manic symptoms and probable bipolar family history. Within the LAMS data, disruptive mood dysregulation disorder was diagnosed twice as much as bipolar disorder not otherwise specified.

Ong, M. L., Youngstrom, E. A., Chua, J. J. X., Halverson, T. F., Horwitz, S. M., Storfer-Isser, A., Frazier, T.W., Fristad, M.A., Arnold, L.E. Phillips, M.L., Birmaher, B., Kowatch, R.A., Findling, R. L., LAMS Group (2016). Comparing the CASI-4R and the PGBI-10M for differentiating bipolar spectrum disorders from other outpatient diagnoses in youth. Journal of Abnormal Child Psychology. 45, 611-623. doi:10.1007/s10802-016-0182-4

This paper used data from the LAMS study to compare the diagnostic accuracy of the Parent General Behavior Inventory-10-item Mania (PGBI-10M) and the Child and Adolescent Symptom Inventory-Revised (CASI-4R), which both have different mania subscales. The findings suggest that the CASI-4R is just as accurate as the PGBI-10M in identifying bipolar spectrum disorders. As clinicians are the intended audience of this paper, the authors report that the accuracy of the CASI-4R is much higher with the parent report subscale than the teacher report subscale.

Portugal, L.C., Rosa, M.J., Bebko, G., Bertocci, M.A., Hinze, A.K., Bonar, L., Almeida, J.R.C., Perlman, S.B., Versace, A., Schirda, C., Travis, M.J., Gill, M.K., Demeter, C., Diwadkar, V.A., Ciuffetelli, G., Rodriguez, E., Forbes, E.E., Sunshine, J.L., Holland, S.K., Kowatch, R.A., Birmaher, B., Axelson, D., Horwitz, S.M., Arnold, E.L., Fristad, M.A., Youngstrom, E.A., Findling, R.L., Pereira, M., Oliveira, L., Phillips, M.L., & Mourao-Miranda, J. (2016). Can emotional and behavioral dysregulation in youth be decoded from functional neuroimaging? PLOS-ONE, 11, doi:10.1371/journal.pone.0117603.

This paper used neuroimaging data from the LAMS study to determine if PGBI-10M scores at different time points could be predicted from specific patterns of brain activity during a reward-processing task using fMRI and pattern regression analysis. The results suggest that pattern recognition models when combined with neuroimaging can allow for estimation of disorder diagnosis and can inform the clinical assessment of psychiatric youth. This paper intends to direct future studies on using neuroimaging and pattern recognition in predicting clinical outcomes in pediatric mood and behavioral disorders.

Van Meter, A. R., You, D. S., Halverson, T., Youngstrom, E. A., Birmaher, B., Fristad, M. A., Kowatch, R.A., Storfer-Isser, A., Horwitz, S.M., Frazier, T.W., Arnold, L.E., Findling, R.L., The LAMS Group. (2016). Diagnostic Efficiency of Caregiver Report on the SCARED for Identifying Youth Anxiety Disorders in Outpatient Settings. Journal of Clinical Child & Adolescent Psychology, 1-15. doi:10.1080/15374416.2016.1188698

This paper used data from the LAMS study to determine the diagnostic and clinical utility of the SCARED-P in screening for pediatric anxiety disorders. This paper is targeted at clinicians who rely on parent report to get the full picture when deciding to diagnose an individual with pediatric anxiety disorder. This is the first paper to report diagnostic likelihood ratios for the SCARED. The results suggest that the SCARED-P subscales of separation anxiety and generalized anxiety disorder have significant accuracy. According to this paper, the SCARED-P is a good measure for screening for youth anxiety disorders.

2014

Arnold, L.E., Ganocy, S.J., Mount, K., Youngstrom, E.A., Frazier, T., Fristad, M., Horwitz, S.M., Birmaher, B., Findling, R., Kowatch, R.A., Demeter, C., Axelson, D., Gill, M.K., Marsh, L. (2014). Three-year latent class trajectories of ADHD symptoms in a clinical sample not selected for ADHD. Journal of the American Academy of Child & Adolescent Psychiatry; 53, 745–760. doi:10.1016/j.jaac.2014.03.007

This paper used data from the LAMS study to investigate trajectories of ADHD symptoms in a population of individuals with pediatric mania symptoms. The results suggest that an ADHD diagnosis results in a better prediction of ADHD symptom trajectory.

Bebko G, Bertocci MA, Fournier J, Hinze AK, Bonar L, Almeida JRC, Perlman SB, Versace A, Claudiu S, Travis M, Gill MK, Demeter C, Vaibhav DA, Rodriguez E, Olino T, Forbes E, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Arnold, LE, Fristad MA, Youngstrom, E.A., Findling RL, & Phillips ML. (2014). Parsing dimensional versus diagnostic category-related patterns of reward circuitry function in behavioral and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms (LAMS) study. JAMA Psychiatry, 71, 71-80. doi: 10.1001/jamapsychiatry.2013.2870

This paper used neuroimaging data from the LAMS study to identify neuroimaging measures correlated with pediatric behavioral and emotional dysregulation in order to understand disorder-specific pathophysiology. The region of interest was the prefrontal-ventral striatal reward circuitry tested during a reward paradigm. As the paper’s primary audience includes fellow neuroimaging researchers, the conclusion suggests that, based on the findings, a dimensional approach to studying the neural mechanisms in behaviorally and emotionally dysregulated youth is the best approach.

Bertocci, M., Bebko, G., Olino, T., Fournier, J., Hinze, A., Bonar, L., Almeida, J., Perlman, S., Versace, A., Travis, M., Gill, M. K., Demeter, C., Diwadkar, V., White, R., Schirda, C., Sunshine, J.L., Arnold, L.E., Holland, S., Kowatch, R.A., Birmaher, B., Axelson, D., Youngstrom, E.A., Findling, R.L., Horwitz, S.M., Fristad, M.A., & Phillips, M.L. (2014). Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth. Psychiatric Services, 44, 2603-2615. doi: 10.1017/S0033291714000087

This paper used neuroimaging data from the LAMS study to identify functional abnormalities emotion regulation neural circuitry involved in different behavioral and emotional dysregulation trajectories. This paper was directed at other neuroimaging researchers to suggest that the lateral prefrontal cortical-amygdala circuitry patterns of function are correlated with severity of behavioral and emotional dysregulation trajectories. This suggests that future research should focus on the lateral prefrontal cortical-amygdala circuitry, especially in treating behavioral and emotional dysregulation in children.

Frazier, T., Youngstrom, E.A., Fristad, M., Demeter, C., Birmaher, B., Kowatch, R., . . . Findling, R. (2014). Improving clinical prediction of bipolar spectrum disorders in youth. Journal of Clinical Medicine; 3, 218-232. doi: 10.3390/jcm3010218

This paper used data from the LAMS study to investigate if classification tree algorithms may improve the identification of individuals at risk for bipolar spectrum disorders. Intended for clinicians, this paper demonstrates the accuracy and ease of use of classification tree algorithms in putting together the clinical information necessary to form a comprehensive assessment compared to other methods, including logistic regression.

Perlman, S.B., Hein, T.C., Stepp, S.D., & The LAMS Consortium (2014). Emotional reactivity and its impact on neural circuitry for attention-emotion interaction in childhood and adolescence. Developmental Cognitive Neuroscience, 8, 100-109. doi:10.1016/j.dcn.2013.08.005

This paper used neuroimaging data from the LAMS study to investigate developing neural circuitry involved in emotion-attention interaction and to assess the effects of individuals differences in emotional functioning within this interaction. This paper was intended for fellow researchers to identify neural markers of individual differences in emotional reactivity within the LAMS population and to point to future sites of research for developing therapies relating to such neural circuitry.

2013

Findling, R.L., Jo, B., Frazier, T.W., Youngstrom, E.A., Demeter, C.A., Fristad, M.A., Birmaher, B., Kowatch, R.A., Arnold, L.E., Axelson, D.A., Ryan, N., Hauser, J.C., Brace, D.J., Marsh, L.E., Gill, M.K., Depew, J., Rowles, B.M., & Horwitz, S.M. (2013). The 24-month course of manic symptoms in children. Bipolar Disorders, 15, 669-79. doi: 10.1111/bdi.12100

This paper used data from the LAMS study to investigate if individuals within the LAMS population exhibited different trajectories of parent-reported manic and biphasic symptoms throughout the first 24 months of the study. This is the first study to assess the progression of manic symptoms in a pediatric population. The main audience of this paper is clinicians and researchers, to whom the authors suggest that resulting outcomes are not consistent in youth with symptoms of mania and that future research is needed.

Hafeman, D., Axelson, D.A., Fristad, M., Kowatch, R., Youngstrom, E.A., Horwitz, S., Birmaher, B., Gill, M.K., Arnold, L.E., Ryan, N., Demeter, C., Frazier, T.W., Rowles, B., Depew, J., Hauser, N., & Findling, R.L., (2013). Phenomenology of Bipolar Disorder, Not Otherwise Specified in Youth: A Comparison of Clinical Characteristics with Bipolar I Disorder. Bipolar Disorders, 15, 240-252. doi: 10.1111/bdi.12054

This paper used data from the LAMS study to identify the differences between children with full syndromal bipolar disorder, children with bipolar disorder not otherwise specified, and children without a bipolar spectrum diagnosis. This paper is intended for clinicians and researchers as part of the discussion about diagnosing children who do not have bipolar disorder, but have episodic moods that cause distress. The paper suggests that children with bipolar 1 disorder and children with bipolar disorder not otherwise specified are very similar and are both different from children without a bipolar spectrum disorder diagnosis. This suggested that pediatric bipolar 1 disorder and bipolar disorder not otherwise specified exist on the same spectrum.

Kowatch, R.A., Youngstrom, E.A., Horwitz, S.M., Demeter, C., Fristad, M., Birmaher, B., Axelson, D., Ryan, N., Frazier, T.W., Arnold, L.E., Young, A.S., Gill, M.K., & Findling, R.L. (2013). Psychiatric medications in the LAMS cohort. Psychiatric Services, 64, 1026-34. doi: 10.1176/appi.ps.201200507

This paper used data from the LAMS study to investigate the frequency of multiple medication use in treating youths with emotional and behavioral disorders. This paper was targeted toward clinicians to deepen the discussion on medicating pediatric emotional and behavioral disorders, especially to assess criticisms of overmedicating children with psychiatric symptoms. The results suggested that the pediatric LAMS population was not overmedicated.

2012

Fristad, M. A., Frazier, T. W., Youngstrom, E. A., Mount, K., Fields, B. W., Demeter, C., … Findling, R. L. (2012). What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses? Bipolar Disorders, 14(5), 497–506.

           https://doi.org/10.1111/j.1399-5618.2012.01034.x

This paper used data from the LAMS study to investigate the effect of family history, family environment, and stress life events in predicting diagnosis of bipolar spectrum disorder in youths seeking outpatient treatment. This paper was geared toward the clinician community, suggesting that a history of parental manic symptoms was a primary predictor of bipolar spectrum disorder in youths, though it and other risk factors had little accuracy in identifying individuals with bipolar spectrum disorder.

Horwitz, S., Demeter, C., Hayden, M., Storfer-Isser, A., Frazier, T. W., Fristad, M. A., … Findling, R. L. (2012). Parents’ perceptions of benefit of children’s mental health treatment and continued use of services. Psychiatric Services (Washington, D.C.), 63(8), 793–801. https://doi.org/10.1176/appi.ps.201100460a

This paper used data from the LAMS study to investigate which benefits are associated with outpatient mental health services for children and to examine if these benefits are consistent throughout the use of mental health services over a period of 6 months. This paper is aimed to inform clinicians of what benefits the psychiatric populations they serve. The results suggested that mental health services that include medication with or without therapy is seen as more beneficial than therapy alone, though perceived benefit of treatment is correlated with length of treatment.

2011

Arnold, L.E., Demeter, C., Mount, K., Frazier, T.W., Youngstrom, E.A., Fristad, M., Birmaher, B., Findling, R.L., Horwitz, S., & Kowatch, R. (2011). Pediatric Bipolar Spectrum Disorder and ADHD: Comparison and Comorbidity in the LAMS Clinical Sample. Bipolar Disorders,13, 509-521. doi: 10.1111/j.1399-5618.2011.00948.x

This paper used data from the LAMS study to investigate the similarities and differences in ADHD and BPSD as well as examine their comorbidity. This paper is aimed at clinicians and researchers to add to the discussion of whether or not ADHD can be an early manifestation of BPSD. The results of the paper suggested that ADHD does not appear to be an early manifestation of BPSD.

Axelson, D.A., Birmaher, B., Findling, R.L., Fristad, M.A., Kowatch, R.A., Youngstrom, E.A., Arnold, L.E., Goldstein, B.I., Goldstein, T., Chang, K.D., DelBello, M.P., Ryan, N.D., & Diler, R.S. (2011). Concerns Regarding the Inclusion of Temper Dysregulation Disorder with Dysphoria in the DSM-5. Journal of Clinical Psychiatry, 72, 1257-1262. doi: 10.4088/JCP.10com06220

This paper used data from the LAMS study to examine the prevalence and longitudinal stability of the proposed diagnosis of TDDD (which evolved into the DMDD diagnosis that DSM-5 included, but ICD-11 did not).

Findling, R.L., Horwitz, S.M., Birmaher, B., Kowatch, R.A., Fristad, M.A., Youngstrom, E.A., Frazier, T.W., Axelson, D., Ryan, N., Demeter, C.A., Depew, J., Fields, B., Gill, M.K., Deyling, E.A., Rowles, B.M., & Arnold, L.E. (2011). Clinical characteristics of children receiving antipsychotic medication. Journal of Child and Adolescent Psychopharmacology, 21, 311-319. doi: 10.1089/cap.2010.0138

This paper used data from the LAMS study to investigate the demographic and diagnostic characteristics of children using antipsychotic medication compared to children using other medication in a population of youths with and without elevated symptoms of mania. The results suggested that the characteristics of being white, having previous hospitalization, having a psychotic or bipolar 1 disorder, and site of treatment were significantly related to being prescribed antipsychotics. Children with psychotic disorders or unmodified bipolar 1 disorder were more likely to be treated with antipsychotics compared to other children within the LAMS cohort.

Frazier, T.W., Youngstrom, E.A., Horwitz, S., Demeter, C., Fristad, M., Arnold, L.E., Birmaher, B., Kowatch, R., Axelson, D., Ryan, N., Gill, M., & Findling, R.L. (2011). The Relationship of Persistent Manic Symptoms to the Diagnosis of Pediatric Bipolar Disorder. Journal of Clinical Psychiatry, 72(6), 846-853. doi: 10.4088/JCP.10m06081yel

This paper used data from the LAMS study to investigate if the presence of persistent manic symptoms in a short amount of time increases the chance of a bipolar spectrum disorder diagnosis. This paper was aimed at clinicians to further the discussion as to whether or not the diagnosis of pediatric bipolar spectrum disorders is a valid diagnosis. The results suggested that clinicians should be careful in diagnosing pediatric bipolar disorders, as repeated parent reports of mania symptoms had a significant impact on the probability of a BPSD diagnosis.

Mendenhall, A.N., Demeter, C., Findling, R.L., Frazier, T.W., Fristad, M.A., Youngstrom, E.A., Arnold, L.E., Birmaher, B., Gill, M.K., Axelson, D.A., Kowatch, R.A., & Horwitz, S.M. (2011). Factors influencing mental health service utilization by children with serious emotional and behavioral disturbance: Results from the LAMS study. Psychiatric Services, 62, 650-658.doi: 10.1176/appi.ps.62.6.650

This paper used data from the LAMS study to investigate the uses of mental health services by children with emotional and behavioral disorders. This paper was aimed at informing clinicians and researchers about the demographic differences in how individual patients benefit from different levels of mental health services. The paper called for more research on type of service use based on demographic characteristics. The paper also suggested that clinicians need to focus more on multimodal treatments.

2010

Findling, R.L., Youngstrom, E.A., Fristad, M.A., Birmaher, B., Kowatch, R.A., Arnold, L.E., Frazier, T.W., Axelson, D.A., Ryan N., Demeter, C.A., Gill, M.K., Fields, B., Depew, J., Kennedy, S.M., Marsh, L., Rowles, B.M., & Horwitz, S.M. (2010). Characteristics of children with elevated symptoms of mania: The Longitudinal Assessment of Manic Symptoms (LAMS) Study. Journal of Clinical Psychiatry, 71, 1664-1672.doi: 10.4088/JCP.09m05859yel

This is the LAMS study, which investigates the demographics, medication, psychiatric symptomatology, and diagnoses in children with elevated symptoms of mania (ESM+) and in children without ESM (ESM-). This paper concluded that more longitudinal analysis was needed to determine the variables involved in pediatric BPSD diagnostic evolution in children with ESM+. The primary audience of this study was clinicians and researchers to provide a large, longitudinal dataset that could be used in research to learn more about pediatric symptoms of mania and bipolar spectrum disorders.