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Progress and Prospects in Parkinson's Research/Causes/Toxins/Dieldrin

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Background

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Dieldrin is an insecticide which was invented in the 1940s. However once it is used it is persistent and seems to gain in toxicity as it passes up through the food chain. It has been linked to a number of diseases in humans and, as a result, it has been banned in many countries.

Research

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2001


Uversky et al [1] showed that pesticides including Dieldrin were responsible for the formation of alpha-synuclein fibrils in dopaminergic neurons.


2005

Kanthasamy et al [2] produced evidence linking Dieldrin to the onset of Parkinson’s Disease.


2006

Richardson et al [3] established the toxicity of Dieldrin to dopaminergic neurons. Their conclusions state:-

"These data suggest that developmental exposure to dieldrin leads to persistent alterations of the developing dopaminergic system and that these alterations induce a "silent" state of dopamine dysfunction, thereby rendering dopamine neurons more vulnerable later in life."


2007

Hatcher et al [4] demonstrated that dopaminergic neurons (in mice) were severely damaged by Dieldrin.

Further Reading

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PAN Pesticides Database. http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33416

2008


Kanthasamy, Anumantha G.; Kitazawa, Masashi; Yang, Yonglie; Anantharam, Vellareddy; and Kanthasamy, Arthi. (2008) Mol. Brain 1. 12.

Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584097/?tool=pmcentrez


2010

Martyniuk, Christopher J.; Kroll.; Doperalski, Nicholas J.; Barber, David S. and Denslow, Nancy D. (2010) Toxicol. Sci. 117 (1) 190-199

Genomic and Proteomic Responses to Environmentally Relevant Exposures to Dieldrin: Indicators of Neurodegeneration?

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923291/?tool=pmcentrez

Search the scientific literature (Dieldrin)

Literature search:

Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- Parkinson's_Disease Dieldrin.
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Causes > Toxins

Sub Pages:

Cadmium - Copper - Dieldrin - Manganese - Maneb - Mercury - MPTP - n-Hexane - Paraquat - Rotenone - Toluene - Trichloroethylene - Ziram

References

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<references>

  1. ↑ Uversky, V.N.; Li, J. and Fink . (2001) FEBS. LET 500 (3) 105-108. Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. http://www.ncbi.nlm.nih.gov/pubmed/11445065
  2. ↑ Kanthasamy, A.G.; Kitazawa, M.; Kanthasamy, A. and Anantharam, V. Neurotoxicology.(2005) 26(4):701-19. Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. http://www.ncbi.nlm.nih.gov/pubmed/16112328
  3. ↑ Richardson, J.R. Caudle, WM.; Wang, M.; Dean, E.D.; Pennell KD. and Miller; G.W. (2006) FASEB J. 20(10):1695-7. Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease. http://www.ncbi.nlm.nih.gov/pubmed/16809432
  4. ↑ Hatcher, Jaime M.; Richardson, Jason R.; Guilot, Thomas S.; McCormack, Alison L. and Di Monte, Donato. (2007) Exp. Neurol. 204(2): 619–630. Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896133/pdf/nihms21643.pdf?tool=pmcentrez
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