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This page lists current researches in developing cures and therapies for different pathologies.

The goal of this page is to be a tool see the current state of each research, how it's progressing or if it had failed.

Please help expand it!

Diabetes type 1

Cell Based Therapeutics^[1]

Diabetes type 2

Kidney failure

Growing a Kidney In-Situ / De novo organogenesis^[2]

Cell Transplantation^[2]

Growing a Kidney In-Vitro^[2]

Reseeding a Kidney: Decellularized Scaffolds^[2]

Bioengineering a Kidney^[2]

Bioartificial Renal Epithelial Cell System (BRECS)^[2]

Implantable Renal Assist Device (iRAD)^[2] / implantable bioartificial kidney (BAK)^[3]

Cancer

Crohn's disease

Bupropion^[4]^[5]^[6]

Major Depressive Disorder

Inflammation-related depression

Studies shows for an elevated cytokines in depressed patients: IL-1β, IL-6, sIL-2R (soluble IL-2 receptors) and TNF-α ^[7] and those cytokines may reduce monoamine levels.^[8]

Konsman present an important critical review paper on the subject.^[9]

Anti-inflammatory Treatment^[10]

References

↑ Zamboni, Fernanda; Collins, Maurice N. (2017-4). "Cell based therapeutics in type 1 diabetes mellitus". International Journal of Pharmaceutics (Elsevier) 521 (1-2): 346–356. doi:10.1016/j.ijpharm.2017.02.063. ISSN 0378-5173. PMID 28242376. https://linkinghub.elsevier.com/retrieve/pii/S037851731730162X.
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Kim, S; Fissell, WH; Humes, DH; Roy, S (2015). "Current strategies and challenges in engineering a bioartificial kidney". Frontiers in bioscience (Elite edition) 7: 215-228. 2015-01-01. ISSN 1945-0494. PMID 25553375. PMC PMC4383659. //www.ncbi.nlm.nih.gov/pmc/articles/PMCPMC4383659/.
↑ Humes, HD; Buffington, D; Westover, AJ; Roy, S; Fissell, WH (March 2014). "The bioartificial kidney: current status and future promise". Pediatric Nephrology 29 (3): 343–351. doi:10.1007/s00467-013-2467-y. ISSN 0931-041X. http://link.springer.com/10.1007/s00467-013-2467-y.
↑ Kast, RE; Altschuler, EL (Nov 2001). "Remission of Crohn's disease on bupropion". Gastroenterology (Elsevier) 121 (5): 1260–1261. doi:10.1053/gast.2001.29467. ISSN 0016-5085. PMID 11706830. https://linkinghub.elsevier.com/retrieve/pii/S0016508501700212.
↑ Mosaic, LS. "Why a third of antidepressants are prescribed for something else". CNN. Retrieved 2019-07-06.
↑ Brustolim, D; Ribeiro-dos-Santos, R; Kast, RE; Altschuler, EL; Soares, MBP (Jun 2006). "A new chapter opens in anti-inflammatory treatments:The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International Immunopharmacology (Elsevier) 6 (6): 903–907. doi:10.1016/j.intimp.2005.12.007. ISSN 1567-5769. PMID 16644475. https://linkinghub.elsevier.com/retrieve/pii/S1567576906000026.
↑ Liu, Yang; Ho, Roger Chun-Man; Mak, Anselm (2012-8). "Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression". Journal of Affective Disorders 139 (3): 230–239. doi:10.1016/j.jad.2011.08.003. ISSN 1573-2517. PMID 21872339.
↑ Yang, Longfei; Zhao, Yinghao; Wang, Yicun; Liu, Lei; Zhang, Xingyi; Li, Bingjin; Cui, Ranji (2015-08-31). "The Effects of Psychological Stress on Depression". Current Neuropharmacology 13 (4): 494–504. doi:10.2174/1570159x1304150831150507. PMID 26412069. PMC PMC4790405. https://www.researchgate.net/profile/Lancelot_Young/publication/281769375_The_Effects_of_Psychological_Stress_on_Depression/links/58ca4d5f92851c4b5e6f685b/The-Effects-of-Psychological-Stress-on-Depression.pdf.
↑ Konsman, JP (2019-02-14). "Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation". Pharmaceuticals 12 (1). doi:10.3390/ph12010029. ISSN 1424-8247. PMID 30769887. PMC 6469164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469164/.
↑ Kopschina Feltes, Paula; Doorduin, Janine; Klein, Hans C; Juárez-Orozco, Luis Eduardo; Dierckx, Rudi AJO; Moriguchi-Jeckel, Cristina M; de Vries, Erik FJ (2017-9). "Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy". Journal of Psychopharmacology (Oxford, England) 31 (9): 1149–1165. doi:10.1177/0269881117711708. ISSN 0269-8811. PMID 28653857. PMC 5606303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606303/.

[1] Zamboni, Fernanda; Collins, Maurice N. (2017-4). "Cell based therapeutics in type 1 diabetes mellitus". International Journal of Pharmaceutics (Elsevier) 521 (1-2): 346–356. doi:10.1016/j.ijpharm.2017.02.063. ISSN 0378-5173. PMID 28242376. https://linkinghub.elsevier.com/retrieve/pii/S037851731730162X.

[kim2015-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Kim, S; Fissell, WH; Humes, DH; Roy, S (2015). "Current strategies and challenges in engineering a bioartificial kidney". Frontiers in bioscience (Elite edition) 7: 215-228. 2015-01-01. ISSN 1945-0494. PMID 25553375. PMC PMC4383659. //www.ncbi.nlm.nih.gov/pmc/articles/PMCPMC4383659/.

[Humes2014-3] Humes, HD; Buffington, D; Westover, AJ; Roy, S; Fissell, WH (March 2014). "The bioartificial kidney: current status and future promise". Pediatric Nephrology 29 (3): 343–351. doi:10.1007/s00467-013-2467-y. ISSN 0931-041X. http://link.springer.com/10.1007/s00467-013-2467-y.

[4] Kast, RE; Altschuler, EL (Nov 2001). "Remission of Crohn's disease on bupropion". Gastroenterology (Elsevier) 121 (5): 1260–1261. doi:10.1053/gast.2001.29467. ISSN 0016-5085. PMID 11706830. https://linkinghub.elsevier.com/retrieve/pii/S0016508501700212.

[5] Mosaic, LS. "Why a third of antidepressants are prescribed for something else". CNN. Retrieved 2019-07-06.

[6] Brustolim, D; Ribeiro-dos-Santos, R; Kast, RE; Altschuler, EL; Soares, MBP (Jun 2006). "A new chapter opens in anti-inflammatory treatments:The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". International Immunopharmacology (Elsevier) 6 (6): 903–907. doi:10.1016/j.intimp.2005.12.007. ISSN 1567-5769. PMID 16644475. https://linkinghub.elsevier.com/retrieve/pii/S1567576906000026.

[7] Liu, Yang; Ho, Roger Chun-Man; Mak, Anselm (2012-8). "Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression". Journal of Affective Disorders 139 (3): 230–239. doi:10.1016/j.jad.2011.08.003. ISSN 1573-2517. PMID 21872339.

[8] Yang, Longfei; Zhao, Yinghao; Wang, Yicun; Liu, Lei; Zhang, Xingyi; Li, Bingjin; Cui, Ranji (2015-08-31). "The Effects of Psychological Stress on Depression". Current Neuropharmacology 13 (4): 494–504. doi:10.2174/1570159x1304150831150507. PMID 26412069. PMC PMC4790405. https://www.researchgate.net/profile/Lancelot_Young/publication/281769375_The_Effects_of_Psychological_Stress_on_Depression/links/58ca4d5f92851c4b5e6f685b/The-Effects-of-Psychological-Stress-on-Depression.pdf.

[9] Konsman, JP (2019-02-14). "Inflammation and Depression: A Nervous Plea for Psychiatry to Not Become Immune to Interpretation". Pharmaceuticals 12 (1). doi:10.3390/ph12010029. ISSN 1424-8247. PMID 30769887. PMC 6469164. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469164/.

[10] Kopschina Feltes, Paula; Doorduin, Janine; Klein, Hans C; Juárez-Orozco, Luis Eduardo; Dierckx, Rudi AJO; Moriguchi-Jeckel, Cristina M; de Vries, Erik FJ (2017-9). "Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy". Journal of Psychopharmacology (Oxford, England) 31 (9): 1149–1165. doi:10.1177/0269881117711708. ISSN 0269-8811. PMID 28653857. PMC 5606303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606303/.

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Medical Research