Precambrian/Life origins

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Welcome to the Wikiversity learning project for Life Origins. Participants in this project explore key originating steps in the evolution of life including the abiotic origin of life, the endosymbiotic origin of eukaryotes, the origin of action potentials and brains, the origin of the human species and the origin of human language.

Organization of this learning project[edit]

At least initially, there are page sections with short introductions and a list of suggested reading. Participants should feel free to learn by editing, in particular, feel free to start subsections for questions and discussion.

Origin of life[edit]

Early speculations about the origin of life were very limited due to the difficulty in revealing details of the chemical basis of life. Naturalists like Darwin could express vague suspicions about the boundary between non-living chemical systems and life, but it was not clear what constituted the most simple forms of life. Experimentalists such as Pasteur began to test how easy it is to make the transition from non-living chemical systems to microbial life, but they had no understanding of the likely differences between environmental conditions in the current biosphere of Earth and conditions when life first arose.

  • Darwin - Darwin (1809-1882) was reluctant to speculate about the origin of life, but in private he speculated that chemical reactions alone, "in some warm little pond, with all sorts of ammonia and phosphoric salts, light, heat, electricity," might have been the origin of life.
  • Louis Pasteur (1822–1895) and the debate of spontaneous generation. When natural selection first became known as a mechanism for change in living systems, very little was known about life at the microscopic level. It was not clear if transition from non-living chemistry to living cells was something that might easily take place at any time. Pouchet (1800-1872) claimed that boiled water and hay provided suitable conditions for the generation of new microbes. Pasteur showed that Pouchet's methods allowed living microbes back into the boiled hay after cooling. After heat sterilization, if care is taken to prevent contamination by living microbes, sterilized materials remain sterile. See: Louis Pasteur. Achievements and disappointments, 1861 by J. R. Porter (1961), starting on page 394.

Modern era[edit]

In the early 1900s biochemistry continued to mature, genetics began as a science and viruses began to be appreciated as very small biologically active agents near the boundary between non-living chemical systems and living cells. It became widely recognized that free oxygen on Earth is of biological origin, with profound implications for the abiotic production of organic molecules.

Although biologists and biochemists have constructed their ideas about the origin of life upon the tenet of the "reducing atmosphere" (i.e. containing no free-oxygen), geologists have never been unanimous. The Ecopoesis model is a recent proposal for a new approach to the issue.


Enzymes vs genes[edit]

The "classical" period of molecular biology revealed the capacity of nucleic acid molecules to function as genetic molecules. Proteins were thought of as the critically important biological catalysts in control of the chemistry of life. All life on Earth depends on a complex process by which genetic information stored in nucleic acid sequences is converted into the structure of proteins.

Francis Crick speculated about possible stages by which an initially simple translation system with a few amino acid types might have evolved into the more complex code used by existing organisms[1]. At that time, everyone thought of proteins as the only kind of enzymes and ribozymes had not yet been found. However, even this speculation about an initially simplified genetic code did not generate much enthusiasm for the idea that a translation system depending on many proteins could evolve from a pre-biological "organic soup". The origin of translation appeared to be an impossible chicken-or-egg problem. Faced with this conceptually baffling problem, Crick and Orgel speculated about the possibility that the original production of living systems might be a very rare event, but once it had happened once it might be spread by intelligent life forms using space travel, a process they called "Directed Panspermia"[2].

Related resource: Origin of translation

Ribozyme era[edit]

The conceptual log-jam in origin of life research was broken by a new fundamental biological discovery made in the 1980s: enzymatically-active RNA.

In a retrospective article, Crick and Orgel noted that they had been overly pessimistic about the chances of abiogenesis on Earth when they had assumed that some kind of self-replicating protein-based system was the molecular origin of life[3]. With the discovery of ribozymes it became possible to imagine an RNA world and the origin of life in the form of possibly a single self-replicating polymer that could function as both a genetic molecule and as a source of enzymatic activities. See also: the RNA World learning resource at Wikiversity.

The fact that RNA is not a particularly stable molecule immediately raises thoughts about the possibility of some other polymer that was more stable than RNA serving as the first genetic molecule. Also, some interest began to shift from the problem of abiotic synthesis of polymers to the related problem of stabilizing useful polymers once they were created.

Another conceptual change from about the same time as the discovery of ribozymes was recognition that many microbes are not dependent on sunlight for energy. New knowledge of microbes that harvest chemical energy in deep sea and deep ground environments, including a diverse collection of extremophiles, has broadened thinking about the possibilities for early chemical systems that might have made the transition to a living state.

Reviewed by Ronald F. Fox (1993). Stuart Kauffman - Wikipedia article.

Life: Classification and Origins[edit]

Figure 1

What are the evolutionary origins of Earth's major forms of life?

Thomas Cavalier-Smith reviewed the issue of life form origins in Deep phylogeny, ancestral groups and the four ages of life. In his Figure 1 (image shown to the right), the origin of Eukaryotes is emphasized.

It has been proposed that early eukaryotic cells had an endomembrane system and membrane-delineated nucleus. Around 850,000,000 years ago, mitochondria originated as endocytosed bacteria.

Figure 1 shows three kinds of photosynthetic life forms (green), categorized as chromista, plants and photosynthetic bacteria. The two types of photosynthetic eukaryotes originated by endocytosis of cyanobacteria.

Figure 3

Microfossil evidence indicates that bacteria were the earliest form of life on Earth. Cavalier-Smith's Figure 3 (image shown to the right) divides the bacteria into two major forms, negibacteria, with two distinct lipid bilayer membranes, and the unimembrana. Cavalier-Smith further divides the unimembrana into Posibacteria and Archaebacteria.

Related resource: Bacterial fossil structure and preservation.

Cavalier-Smith has suggested that enough oxygenic photosynthesis took place approximately 2,500,000,000 years ago to cause removal of methane from the atmosphere, resulting in a Palaeoproterozoic global freeze.

Anaerobic photosynthetic bacteria similar to extant Chloroflexi probably existed prior to the evolution of Photosystem II. Stromatolites have been reported that date to over 3,000,000,000 years old.

Related resources[edit]

References[edit]

  1. "The origin of the genetic code" by F. H. C. Crick in J Mol Biol. (1968) Volume 38 pages 367-379. Entrez PubMed 4887876
  2. "Directed Panspermia” by Francis Crick and Leslie E Orgel in Icarus (1973) Volume 19 pages 341-346. Crick later wrote a book about directed panspermia called Life Itself (Simon & Schuster, 1981) ISBN 0-671-25562-2
  3. "Anticipating an RNA world. Some past speculations on the origin of life: where are they today?" by L. E. Orgel and F. H. C. Crick in FASEB J. (1993) Volume 7 pages 238-239.