WikiJournal of Medicine/Plasmodium falciparum erythrocyte membrane protein 1/XML

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    <full_title>WikiJournal of Medicine/Plasmodium falciparum erythrocyte membrane protein 1</full_title>
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     <doi>10.15347/WJM</doi>
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   <journal_issue>  
    <publication_date media_type='online'>     
     <year>2019</year>  
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    <titles>     
     <title>Plasmodium falciparum erythrocyte membrane protein 1</title>
    </titles>   
    <contributors>
    <person_name sequence='first' contributor_role='author'>
     <surname>Lalchhandama</surname><given_name>Kholhring</given_name><ORCID>http://orcid.org/0000-0001-9135-2703</ORCID>
    </person_name>  
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    <publication_date media_type='online'>     
     <year>2019</year>
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    <doi_data>     
     <doi>10.15347/wjm/2017.004</doi>     
     <resource>https://en.wikiversity.org/wiki/WikiJournal of Medicine/Plasmodium falciparum erythrocyte membrane protein 1</resource>
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     <license-p>[[File:Open_Access_logo_PLoS_white.svg|11px|link=Wikipedia:Open Access]] [[File:Cc.logo.circle.svg|16px|link=Wikipedia:Creative Commons]]
This is an open access article distributed under the&nbsp;[https://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution License], which permits unrestricted use, distribution, and reproduction, provided the original author and source are credited.</license-p>
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   <abstract>
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''Plasmodium falciparum'' erythrocyte membrane protein 1 (PfEMP1) is a family of proteins present on the membrane surface of red blood cells (RBCs or erythrocytes) that are infected by the malarial parasite ''Plasmodium falciparum''. PfEMP1 is synthesized during the parasite's blood stage (erythrocytic schizogony) inside the RBC, during which the clinical symptoms of falciparum malaria are manifested. Acting as both an antigen and adhesion protein, it is thought to play a key role in the high level of virulence associated with ''P. falciparum''. It was discovered in 1984 when it was reported that infected RBCs had unusually large-sized cell membrane proteins, and these proteins had antibody-binding (antigenic) properties. An elusive protein, its chemical structure and molecular properties were revealed only after a decade, in 1995. It is now established that there is not one but a large family of PfEMP1 proteins, genetically regulated (encoded) by a group of about 60 genes called ''var''. Each ''P. falciparum'' is able to switch on and off specific ''var'' genes to produce a  functionally different protein, rendering evasion from the host's immune system. RBCs carrying PfEMP1 on their surface stick to endothelial cells, which facilitates further binding with uninfected RBCs (through the processes of sequestration and rosetting), ultimately helping the parasite to both spread to other RBCs as well as bringing about the fatal symptoms of ''P. falciparum'' malaria.
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