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Studies by Martin Harrow on treatment of schizophrenia

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This small article by Dan Polansky intends to catalogue studies by Martin Harrow on treatment of schizophrenia by antipsychotics/neuroleptics. It further intends to support evaluation of these studies.

Given the later studies state that long-term outcomes of patients who do no use antipsychotics are better than those who do use antipsychotics, these studies seem very important for schizophrenia patients. However, if the results of these studies are in fact misleading, the studies can cause harm by contributing to patients abandoning antipsychotic medication for wrong reasons. It is therefore vital to see what kinds of criticism apply to the studies and find out to what extent the criticism is valid. On the other hand, evaluating the criticism can be a challenging task, expecially for a non-expert.

One criticism is that these are not blinded studies and that it is not clear that it is the antipsychotics that lead to worse long-term outcomes. It could be--at least in principle--that those doing worse have worse initial prognosis or worse underlying condition.

For a start, we link to a 2023 article by Robert Whitaker that links to either all of the Harrow studies or to the most important ones. Links to the studies themselves are to be added later; we at least link to the latest study by Harrow, published electronically in 2021¨. Since Harrow died, no more studies from him are coming.

It is to be clarified what longitudinal study refers to exactly.

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