Progress and Prospects in Parkinson's Research/Symptoms/Motor fluctuations

Motor fluctuations

'On-off' periods, wearing off, dose failures, and freezing associated with long-term levodopa use

The following references are relevant:-

Bordelon et al (2011) Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease ^[1]/

Bohnen et al (2011) Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease ^[2]

Mera et al (2012) Feasibility of home-based automated Parkinson’s disease motor assessment ^[3]

Further Research

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References

↑ Bordelon, Yvett;M.; Hayes, Ron D,; Vassar, Stefanie D.; Diaz, Natalie; Bronstein, Jeff and Vickrey, Barbra, G. (2011) Full Text Parkinsons Dis. 2001 967839 Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236449
↑ Bohnen, Nicolaas I.; Muller, Martijn L.T.M.; Zarzhevsky, Natalia; Koeppe, Robert A.; Bogan, Christopher W.; Kilbourn, Michael R.; Frey, Kirk A. and Albin, Roger L.(2011) Full Text Brain 134 (8) 2358 – 2365 Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155702/
↑ Mera, Thomas O.; Heldman, Dustin (2012) Full Text J. Neurosci. Methods 203 (1) 152 – 156. Feasibility of home-based automated Parkinson’s disease motor assessment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221741/

[1] Bordelon, Yvett;M.; Hayes, Ron D,; Vassar, Stefanie D.; Diaz, Natalie; Bronstein, Jeff and Vickrey, Barbra, G. (2011) Full Text Parkinsons Dis. 2001 967839 Medication Responsiveness of Motor Symptoms in a Population-Based Study of Parkinson Disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236449

[2] Bohnen, Nicolaas I.; Muller, Martijn L.T.M.; Zarzhevsky, Natalia; Koeppe, Robert A.; Bogan, Christopher W.; Kilbourn, Michael R.; Frey, Kirk A. and Albin, Roger L.(2011) Full Text Brain 134 (8) 2358 – 2365 Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson’s disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155702/

[3] Mera, Thomas O.; Heldman, Dustin (2012) Full Text J. Neurosci. Methods 203 (1) 152 – 156. Feasibility of home-based automated Parkinson’s disease motor assessment http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221741/

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