Progress and Prospects in Parkinson's Research/Atypical Parkinsonism/Corticobasal Degeneration (CBD)

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Corticobasal Degeneration is a neurological disease, the symptoms of which can be difficult to distinguish from Parkinson's Disease

Background[edit | edit source]

CBD is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. It is a progressive, incurable and largely untreatable condition, the causes and pathology of which have yet to be determined

Onset is generally around the age of 60 and an average fatal outcome is 8 years. Typical symptoms include bradykinesia, freezing, impaired balance, rigidity, muscle jerks, visual and cognitive impairment, swallowing problems and speeh impediments. Many patients lose the ability to walk.

Research[edit | edit source]


Mastrolilli et al [1] reviewed the diagnostic criteria for CBD.

Molecularly CBD is a taupathy, characterised by accumulation of abnormal filamentous inclusions of hyperphosphorylated tau-protein in neurons and glia, similarly to Progressive Supranuclear Palsy (PSP), and some forms of frontotemporal dementia with Parkinsonism. This molecular overlap, especially with PSP is very argued, and whether they are the extremities of the spectrum of a single disorder or two different disorders with a similar genetic predisposition is not clear.

Further Reading[edit | edit source]


Litvan, I.; Agid, Y.; Goetz, C.; Jankovic, J.; Wenning G.K.; Brandel, J.P.; Lai, E.C.; Verny, M.; Chaudhuri,K. Ray; McKee, A.; Jellinger, K; Pearce, R.K.B. and Bartko,Abstract J.J. Abstract Neurology 48 (1) 119-125.

Accuracy of the Clinical Diagnosis of Corticobasal Degeneration- A Clinicopathologic Study.


Ana Herrero Valverde, Ana; Sónia Costa, Timoteo, Ângela; Timoteo, Ginestal, Ricardo and Pimental, José. Full Text Case Rep. Neurol. 3(2): 185–190.

Rapidly Progressive Corticobasal Degeneration Syndrome


Use the following links to query the PubMed, PubMed Central and Google Scholar databases using the Search terms:- CBD diagnosis.

This will list the latest papers on this topic. You are invited to update this page to reflect such recent results, pointing out their significance.

Pubmed (abstracts)

Pubmed_Central (Full_Text)


Related Pages[edit | edit source]

< Back to: Atypical parkinsonism

References[edit | edit source]


  1. Mastrolilli, F.; Benvenga, A.; Di Biase, L.; Giambattistelli, F.; Trotta, L.; Salomone, G.; Quintiliani,L.; Landi, D.; Melgari, J. .; and Vernieri, F. (2011) Full Text Int. J. Alzheimers Dis. 2011: 536141. An Unusual Cause of Dementia: Essential Diagnostic Elements of Corticobasal Degeneration—A Case Report and Review of the Literature