Genetics/CD69
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CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is one of six genes located in human chromosome region 12p13.31. CD69 is expressed on activated T-cells and B-cells. Its induction stimulates TGF-β1 and TGF-β2 synthesis and down regulates immune response. [1]
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- ↑ J Clin Invest. 2003;112(6):872–882. doi:10.1172/JCI19112. CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis