C957T
The C957T gene polymorphism is a single nucleotide synonymous mutation located within the coding region of the DRD2 gene. Rather than being ‘silent’ the C allele influences mRNA stability and translation. As a result, the C allele alters dopamine-induced up-regulation of the D2 receptor. [1] Individuals with the CC genotype make a greater number of preservative errors on the Wisconsin Card Sorting Test [2] and exhibit a reward-related impulsivity endophenotype in response to acute psychosocial stress. [3] The CC genotype interacts with the COMT Val158Met polymorphism [4]
and is associated with schizophrenia. [5] The CC genotype also interacts with the TaqI-A polymorphism of the ANKK1 gene and is associated with dissocial personality disorder. [6]
References
[edit | edit source]- ↑ http://hmg.oxfordjournals.org/content/12/3/205.full
- ↑ http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowAbstract&ProduktNr=224082&Ausgabe=232803&ArtikelNr=98652
- ↑ http://www.springerlink.com/content/du331488l13q8278/
- ↑ http://www.ncbi.nlm.nih.gov/pubmed/17113268
- ↑ http://www.schres-journal.com/article/S0920-9964(04)00306-8/abstract
- ↑ http://bjp.rcpsych.org/cgi/reprint/193/2/121.pdf