Genetics/CLEC2D
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C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene. [1] It is called C-type lectin-like because it has lost the Ca2+-dependent carbohydrate recognition domain present in most conventional C-type lectins while maintaining partial structural similarities. [2] It is one of six genes located in human chromosome region 12p13.31. [3] Several CLEC2D gene transcripts have been described. They are expressed primarily in hematopoietic cells. Lectin-like transcript 1 (LLT1) is expressed on the surface of natural killer cells and some T-cells. Its ligand is CD161. [4]
References
[edit | edit source]- ↑ "Entrez Gene: CLEC2D C-type lectin domain family 2, member D".
- ↑ Weis W. I., Taylor M. E., Drickamer K. (1998) Immunol. Rev. 163, 19–34. The C-type lectin superfamily in the immune system.
- ↑ http://t1dbase.org/page/Overview/display/locus_id/257
- ↑ J Biol Chem. 2010 November 12; 285(46): 36207–36215. PMCID: PMC2975243 Characterization of Alternatively Spliced Transcript Variants of CLEC2D Gene. Claire Germain et al