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Summary
DescriptionIllustration of C. elegans response against exogeneous dsRNA.png
English: Illustration of C. elegans response against exogeneous dsRNA. First five steps, endogeneous steps, are the similar with mammals endogeneous RNAi steps described at Part 1, 2, 3, 4, 5. SiRNAs enters the cell by means of SID-1. Then primary siRNAs are produced by the help of various proteins containing rde-1, rde-4, dcr-1, drh-1/2. And then RISC generated based on rde-1/ guide strand associated structure. Some of remaining parts of exogeneous RNA behave as primer for secondary siRNAs by the work of RNA dependent RNA polymerase (RdRp). PIR- 1 dephosphorylates 2nd siRNAs, produced by RdRP [1]. After that these siRNAs associate with Ago proteins that are different from first ones and called as secondary Ago proteins (SAGO). Further RISC is formed with SAGO and target molecules are processed.
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