Portal:GreySmith Institute new/About13

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Magnetic Resonance chemistry Lab[edit | edit source]

When MDI was invented as a method of utilizing an MRI to get higher resolution pictures, it implied the existence of magnetic particles being used as a stain to detect finer details. Instead of detecting the resonance of normal atoms the design was to detect the resonance of stained elements using the detection of magnetic particles. Just as in electron microscope images, the stain provides the contrast between areas that are not interesting and areas that are. The primary difference is that MDI can be done while a subject is alive, while electron microscopy requires that the subject be dead, and diced into small cubes, then sliced into thin layers. the secondary difference is that MDI can't approach the same level of resolution as electron microscopy, but it stores a more holistic picture that can be sliced and diced up to the limit of the resolution.

To make MDI work we need staining techniques that deposit magnetic particles into tissues, at strategic places. The limits to this technology are more the limits of the staining techniques than the resolution, although the images definitely do not have the resolution of electron microscopy. In this laboratory, we will be experimenting with magnetic staining techniques.