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The formation of hard nobs at the middle finger joints (known as Bouchard's nodes) and at the farther away finger joint (known as Heberden's node) are a common feature of osteoarthritis in the hands. Credit: Drahreg01.

Osteoarthritis is a lecture and part of the gene transcription series.

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Yes or No, Osteoarthritis is usually considered a degeneration of joint cartilage and the underlying bone, most common from middle age onward.



True or False, A cell that makes up the tissue of cartilage is called a chondrocyte.



Chondrocytes, the only cell type present in cartilage, have very low metabolism activity with no ability to repair



Yes or No, Articular cartilage, once damaged, cannot respond by a usual inflammatory response because it is non-vascularized and non-innervated.



Yes or No, Apple, carrot, potato, hazelnut and birch reactivity was transferable in Prausnitz-Küstner test like IgE antibodies.



Which of the following is characteristic of the innate immune system?

a non-specific immune system
comprises the cells and mechanisms that defend the host from infection by other organisms in a non-specific manner
triggered after the binding of pathogen-associated molecular patterns (PAMPs)
triggered after the binding of danger-associated molecular patterns (DAMPs) on pattern-recognition receptors (PRRs)
not a driver of the OA process


Yes or No, Once degraded, cartilage fragments fall into the joint and contact the synovium.



Which of the following are phenomena associated with the synovial membrane?

a thin lining layer within the joint cavity
responsible for maintaining normal joint function and homeostasis
normally highly synthetic fibroblast-like synovial (FLS) cells or synoviocytes
primary source of articular hyaluronic acid and other glycoproteins such as lubricin
uridine diphosphoglucose dehydrogenase, galectin 1 and galectin 3
protein product of chromosome 19 open reading frame 10


Yes or No, Any part of the body where two bones join, in most cases allowing that part of the body to be bent or straightened is called a joint.



Complete the text:

Synoviocytes participate in complex

and paracrine activation networks with

, lymphocytes, and dendritic cells, which serve to sustain the

and to enhance its destructive



  1. Osteoarthritis can be reversed by reprogramming gene expression.

See also[edit]

External links[edit]

{{Anthropology resources}}{{Gene project}}

{{Phosphate biochemistry}}