File:Notch signaling plays a crucial role in melanocyte development..jpg

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Description
English: Melanocyte-lineage specific ablation of RBP-J, an essential transcriptional mediator for Notch signaling, results in severe dilution of hair pigmentation (A). This is due to apoptotic elimination of melanoblasts during development. To test whether Notch signaling plays a role in melanocyte stem cells, the first hairs were shaved to induce the second hair cycling (B, circled area). The mice also exhibit premature hair graying from the second postnatal hair cycle (B), indicating an indispensable role of Notch signaling in the maintenance of melanocyte stem cells.
Date Published June 30, 2009.
Source

[1] Direct
StemBook Figure 6 Notch signaling plays a crucial role in melanocyte development.

  • Osawa,M., Melanocyte stem cells (June 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.46.1, http://www.stembook.org.
Author Osawa,M., Melanocyte stem cells (June 30, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.46.1, http://www.stembook.org.
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current18:39, 5 April 2013Thumbnail for version as of 18:39, 5 April 2013500 × 210 (58 KB)SmallbotUploading CC-BY images from the the StemBook http://www.stembook.org/ 30/173

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