Medical biochemistry

Biochemistry for Medicine and Pharmacy

A course of the

Please refer also to the main topic:Biochemistry wiki for Biochemistry for Chemistry and for Biology.

You are invited to improve thoughtfully upon these subjects. Please refer to the Discussion page for proposals, discussion and comments.

Topics and Learning Materials

Basics The International System of Units, item Nomenclature of organic chemistry,item, w:Logarithms w:Nuclides w:Radioactive decay w:gas laws, Gases and Gas Laws w:Partial pressure and w:mole fraction w:Osmosis w:Diffusion pH (needs a little more) Buffers Biomolecules -- Structures, classification and properties of: w:Nucleic acids w:Amino acids w:Protein w:Carbohydrate w:Lipid Laboratory and Analytical Methods Simple (glass) laboratory equipment and how to use it Laboratory safety w:Size exclusion chromatography UV-VIS Spectrometry IR spectrometry Centrifugation and w:Ultracentrifugation w:Electrophoresis w:Chromatography Gas chromatography and mass spectrometry Gamma counting Beta counting w:Enzyme assays w:PCR Metabolic pathways Proteins In vivo nucleic acids synthesis Nucleic acid degradation, pyrimidine and purine catabolism w:Peptide bond In vivo protein synthesis w:Micronutrients and w:Vitamins w:Enzymes Regulation of metabolic pathways Associated: w:Hemoglobin, gas transportation and Hemoglobinopathies

Amino acids w:Decarboxylation w:Transamination General amino acid synthesis General amino acid catabolism Special amino acid metabolism Amino acid interconversion w:Urea cycle, item Gamma-glutamyl cycle Associated: w:Gout,w:Maple syrup disease, w:inborn errors of metabolism Carbohydrates w:Glycolysis Krebs' cycle w:Pyruvate decarboxylation The ATP cycle w:Oxidative phosphorylation Dickens-Horecker cycle Hexose interconversions w:Neoglucogenesis w:Glycogenesis w:Glycogenolysis w:Cori cycle Carbohydrate regulation mechanism: w:glucagon and w:insulin Associated: w:Diabetes mellitus Lipids w:fatty acids Essential fatty acids, item, poly-unsaturated fatty acids (w:PUFA); w:eicosanoids: w:prostaglandins, w:thromboxanes, w:prostacyclin and w:leukotrienes. The w:lipid bilayer, item, and transport across it w:Lipid peroxidation Acylglycerols Triacylglycerols Sn system w:Carnitine and membrane transport of fatty acids w:Fatty acid oxidations w:Beta oxidation w:Ketogenesis Lipid synthesis (w:lipogenesis) w:Arachidonic acid cascade and the eicosanoids (above) Associated: ... w:Lipoproteins and cholesterol The serum lipoprotein transport system w:Cholesterol metabolism, regulation and transport Lipoprotein metabolism w:Chylomicra and w:VLDL w:LDL and w:HDL Regulation of lipoprotein metabolism w:History of Biochemistry

Topics in Veterinary Medicine

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Learning Projects

Biochemistry today

1. The pet food crisis and Non-protein nitrogen as legitimate and illegitimate feed additive.

Essay and Discussion Themes

1. w:Atherosclerosis
   1. Lipoprotein cell recognition mechanisms
   2. Scavenger system
   3. w:Cell adhesion molecules (CAMs). w:Cytokines.
   4. Oxidized lipoproteins
2. w:Digestion and absorption
3. Plasma buffer systems
4. Kidney
5. w:Nerve impulse, transmission, w:neuromuscular junction and modulators.
6. Chemical military agents and w:antidotes
7. w:The origin of life on Earth
8. The possible origin of life outside Earth (w:Astrobiology)
9. Iron, w:Heme and w:Hemoglobin metabolism and its errors (item, item, item)
10. w:Coagulation
11. Voluntary w:Muscle (item) metabolic peculiarities (item, item, item) and the w:neuromuscular junction
12. w:Connective tissue (w:collagen, w:elastin, w:reticulin) and its main anomalies.
13. w:Nicotine toxicology and w:addiction, w:tolerance (item), w:dopamine and the brain reward pathways

• Vitalism - Is vitalism dead? Is mechanicism firmly established? Are all life processes, including consciousness, emotions, feelings (sentiments), and the sense of being oneself (Self) chemical and organic processes and functions, as neurologist António Damásio says ([1], [2], [3])? Is there a life force that drives the processes of the emergence of life on Earth, growth, tissue differentiation, morphogenesis ([4][5]) and of tissue repair? Something like the egyptians Ka ([6]) ? It's true that the controversy between materialism and idealisms has thousands of years and is likely to stay around; but what do you think yourself?

Books

By alphabetical order of the first author's surname.

General Biochemistry

• Nelson DL, Cox MM. "Lehninger Principles of Biochemistry". Worth Publishers. New York. 2000. ISBN 1-57259-153-6. http://worthpublishers.com/lehninger

• Osgood M, Ocorr K. "The Absolute, Ultimate Guide to Lehninger Principles of Biochemistry Study Guide and Solution Manual". Worth Publishers. New York. 2000. ISBN 007-1256300-9.

• Biochemistry Wikibook

Medical Biochemistry

• Cooper GM. The Cell, A Molecular Approach [7]

• Devlin TM Ed. "Textbook of Biochemistry with Clinical Correlations". Wiley-Liss. Hoboken. 2006. ISBN 13978-0-471-67808-3.

• Epstein RJ. "Human Molecular Biology: An Introduction to the Basis of Health and Disease". Cambridge University Press. G. Canale & C. S.p.a. 2003. ISBN 0-521-64481

• Free Books for Doctors - Biochemistry [8]

• Murray RK, Granner DK, Rodwell VW et al. "Harper's Illustrated Biochemistry". Lange-McGrawHill. Singapore. 2006. ISBN 007-125300-9.

• Smith C, Marks A, Liebermann M. "Mark's Basic Medical Biochemistry: A Clinical Approach." Lippincott Williams & Wilkins. Baltimore. 2005. ISBN 0-7817-2145-8

• Stryer's. Missing Up-to-date Reference.
• Stryer's online Biochemistry

Further Resources

• NCBI Bookshelf

• The more general Entrez

• Online Biology Book [9] or [10]

• Exercises