Dissocial personality disorder

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Dissocial personality disorder is a subtype of personality disorder. People who suffer from this disorder have very specific phenotypic and genotypic traits.

The dissocial phenotype[edit]

In order to meet the definition of dissocial personality disorder, an individual must exhibit at least three of the following traits: [1]

  1. a callous unconcern for the feelings of others;
  2. a gross and persistent attitude of irresponsibility and disregard for social norms, rules and obligations;
  3. an incapacity to maintain enduring relationships, though having no difficulty in establishing them;
  4. a very low tolerance to frustration and a low threshold for discharge of aggression, including violence;
  5. an incapacity to experience guilt or to profit from experience, particularly punishment; and
  6. a marked proneness to blame others, or to offer plausible rationalizations, for the behavior that has brought the patient into conflict with society.

The dissocial genotype[edit]

Dissocial personality disorder is characterised by a particular pattern of genetic mutations in and near the DRD2 gene on chromosome 11. Most people have two copies of chromosome 11. Mutations must be present on both copies of the chromosome for an individual to be at risk of developing dissocial personality disorder. The mutations associated with dissocial personality disorder are: [2]

  1. the TaqI-A polymorphism of the ANKK1 gene, and
  2. C957T polymorphism of the DRD2 gene.

In order to be at risk of dissocial personality disorder, an individual must carry at least one copy of the TaqI-A A1 allele as well as two copies of the C allele of the C957T polymorphism. Most alcoholics with the dissocial genotype have dissocial personality disorder. However, there are many latent psychopaths who carry the dissocial genotype but do not meet the clinical definition of dissocial personality disorder.

References[edit]

  1. http://www.mental-health-today.com/articles/pd.htm
  2. http://bjp.rcpsych.org/cgi/reprint/193/2/121.pdf